Investigating the increased lifespan in C. elegans daf-2 mutants by 4D-Lipidomics

4D-Lipidomics™ workflow for increased throughput Lipid profiling from complex lipid extracts can be a challenging and time consuming task. The high complexity of samples and co-elution of isobaric or isomeric compounds complicate the confident annotation of lipids. The presented 4D-Lipidomics…

Using Parallel Accumulation Serial Fragmentation (PASEF) to speed up untargeted 4D lipidomics LC-MS/MS workflows The search for new and validated biomarkers is of particular interest in clinical areas like oncology [1, 2] or neurology [3]. As lipids play an important…

Intensity (arb. unit) 132% 0% 100% PS 38:1 m/z 816.5747 ± 0.0122 1/K0 1.433 ± 0.01 Intensity (arb. unit) Mobility [1/K0] 136% 0% 100% PE 20:1_22:6 m/z 816.5517 ± 0.0122 1/K0 1.404 ± 0.01 m/z 1 mm CCS-aware SpatialOMx® enables…

Incorporating CCS values to enable 4-dimensional annotation of metabolic features Reliable annotation of metabolites for LC-MS/MS based data requires the adept combination of many parameters. To extend our parameter portfolio we analyzed trapped ion mobility spectrometry (TIMS) data. Introduction Experimental…