In Depth Analysis of Host Cell Proteins from Antibody Preparations using PASEF

High-sensitivity Host Cell Protein (HCP) analysis on a new Orbitrap Excedion Pro BioPharma hybrid mass spectrometer with optimized sample preparation Xiaoxi Zhang1, Reiko Kiyonami2, Jae Choi3, Bhavin Patel3, Cong Wang4, Peter Krueger4, Heiner Koch4, Min Du2. 1 Thermo Fisher Scientific,…

Confident LC-MS Identification of Low ppm Host Cell Proteins (HCPs) in Biotherapeutic Monoclonal Antibodies Amy J Claydon1, Phil Widdowson1, Andrew Williamson2, and Min Du3, Thermo Fisher Scientific, 1Runcorn, UK, 2Hemel Hempstead, UK, 3Cambridge, MA, USA Label-free quantification of NISTmAb HCPs…

APPLICATION NOTE 73412 Residual host cell protein analysis of NISTmAb: From simplified sample preparation to reliable results Authors: Amy Claydon, Phil Widdowson, and Andrew Williamson Thermo Fisher Scientific, Hemel Hempstead, UK Keywords: Host cell protein assay, HCP, monoclonal antibody, mAb,…

Increasing sensitivity of high throughput host cell protein analysis on a novel highresolution accurate mass platform Eugen Damoc1; Tabiwang N. Arrey1; Anna Pashkova1; Eduard Denisov1; Kai Scheffler2; Kristina Srzentić3 1Thermo Fisher Scientific (Bremen) GmbH, Bremen, Germany; 2Thermo Fisher Scientific, Germering,…