High-performance MALDI imaging analysis of on-tissue digested proteins in mammalian FFPE tissues using the Bruker rapifleX MALDI-TOF/TOF

High-speed MALDI-TOF/TOF imaging of mouse brain tissue performed on intact proteins and after on-tissue digestion The unique flexibility of MALDI-TOF/TOF systems facilitates tissue imaging of intact proteins as well as of tryptic peptides resulting from on-tissue digestion. While intact protein…

MALDI FTMS Imaging Mass Spectrometry of N-glycans as Tissue Biomarkers of Cancer In this application note, we describe preparation and imaging analysis of N-glycans from formalin-fixed paraffin embedded (FFPE) tissues using the solariX MALDI FTMS. N-glycosylation is a common post…

MALDI Mass Spectrometry Imaging Reveals Distinct Spatio-Molecular Phospholipid Distributions in Mouse Lungs While phospholipids play key roles in lung physiology and pathology, the complex composition and function of the lipidome in the lungs is poorly understood. We applied MALDI mass…

The Ease of Use workflow — A simple way to set up MALDI Imaging measurements MALDI Mass Spectrometry Imaging (MSI) as a versatile and robust tool for analyzing different types of analytes in various samples requires a well-thought-out experiment setup.…