High Definition Data Directed Analysis (HD-DDA)

High Definition Multiple Reaction Monitoring: The Application of Quadrupole Ion Mobility Time-of-Flight Mass Spectrometry for Targeted Proteomics Studies Dominic Helm,1 Christopher J. Hughes,2 James I. Langridge,2 Keith Richardson,2 Arkadiusz Grzyb,2 Jason Wildgoose,2 and Bernhard Kuster1 1 Technische Universität München, Freising,…

Targeted High Resolution Quantification with Tof-MRM and HD-MRM Nick Tomczyk, Alistair Wallace, Keith Richardson, Arkadiusz Grzyb, Jason Wildgoose G OA L Tof-MRM and HD-MRM workflows enable users to To enable routine quantification at very low limits while providing the sensitivity…

[ TECHNOLOGY BRIEF ] Enhanced Glycopeptide Identification Using the SYNAPT XS Q-ToF with Ion Mobility Enabled Wideband Enhancement Christopher J. Hughes,¹ Sakari Joenväärä,² Robert S. Plumb,³ Lee A. Gethings,¹ and Risto Renkonen⁴ ¹Waters Corporation, Wilmslow, UK; ²Haartman Institute, University of…

DEVELOPMENT OF A MODIFIED CYCLIC IMS PLATFORM FOR ENHANCED BIOMOLECULE CHARACTERIZATION Bryan J. McCullough1, Dale A. Cooper-Shepherd1, Darren Hewitt1, David Harker1 & Emma Marsden-Edwards1 1. Waters Corporation, Stamford Avenue, Altrincham Rd., Wilmslow, UK INTRODUCTION Tof duty cycle is inherently limited…