PRESSURIZED ONLINE PEPSIN DIGESTION OF PROTEINS FOR HYDROGEN/DEUTERIUM EXCHANGE MASS SPECTROMETRY

[ APPLICATION NOTE ] Pressurized Online Pepsin Digestion of mAb IgG2 for Hydrogen Deuterium Exchange Mass Spectrometry Jing Fang, Ying Qing Yu, and Weibin Chen Waters Corporation, Milford, MA, USA APPLICATION BENEFITS INTRODUCTION An enhanced-pressure (up to ~ 15,000 psi),…

TECHNICAL NOTE 65887 Hydrogen deuterium exchange mass spectrometry for protein structural characterization Authors: Terry Zhang and Rosa Viner Thermo Fisher Scientific, San Jose, CA, USA Keywords: Peptide mapping, protein conformation, bottom-up, deuterium uptake, hydrogen deuterium exchange mass spectrometry, HDX-MS, HDX,…

Conformational Characterization of Calmodulin by Hydrogen Deuterium Exchange Mass Spectrometry Joomi Ahn, Martha Stapels, Michael Eggertson, Keith Fadgen, and Ying Qing Yu Waters Corporation, Milford, MA, U.S. A P P L I C AT I O N B E N…

[ TECHNOLOGY BRIEF ] Enhanced Performance of the SYNAPT XS and Its Impact on Hydrogen Deuterium Exchange Mass Spectrometry (HDX MS) Data Quality Lindsay Morrison, Malcolm Anderson, and Colette Quinn Waters Corporation, Milford, MA, USA The SYNAPT XS provides enhanced…