Integrating Ion Mobility into Routine Drug Metabolite Identification Studies Using the Vion IMS QTof Mass Spectrometer

[ APPLICATION NOTE ] Metabolite Identification: Working with Large Preclinical Multispecies Data Sets Mark Wrona, 1 Sherri Naughton, 1 Yun Alelyunas, 1 Russell Mortishire-Smith, 2 and Jayne Kirk 2 1 Waters Corporation, Milford, MA, USA 2 Waters Corporation, Wilmslow, UK…

[ APPLICATION NOTE ] Ion Mobility-enabled Data-dependent Experiments Distinguishing Co-eluting Isomeric Metabolites Using an IMS-QTof Mass Spectrometer Jayne Kirk, 1 Russell Mortishire –Smith, 1 Robert Beecher, 1 Richard Clayton, 2 Catherine Holsworth 2 and Mark Wrona3 1 Waters Corporation, Wilmslow,…

[ APPLICATION NOTE ] Ion Mobility-Enabled Metabolite Identification of Tienilic Acid and Tienilic Acid Isomer Using Mass-MetaSite and WebMetabase Lauren Mullin, 1 Giorgis Isaac, 1 Ian Wilson, 2 Adam King, 3 Nathan Anderson, 1 Russell Mortishire-Smith, 3 Robert Plumb 1…

Utilisation of Ion Mobility Enabled Collisional Cross Section Measurements for the Comparison of Metabolites across Differing Chromatographic Methods Catherine Holdsworth*, Richard Clayton, Helen Robinson, Callum Lord-Mears and John Kendrick Covance Laboratories Ltd., Harrogate, UK Introduction During the conduct of metabolite…