Quantitative Method for the Determination of Potentially Mutagenic Impurities of Ondansetron Using UPC2 Coupled with a Xevo TQ-S micro

[ APPLICATION NOTE ] Exploiting the Orthogonality of the ACQUITY UPC2 System to Develop an Impurities Method for Ondansetron Jennifer Simeone, Paula Hong and Patricia R. McConville Waters Corporation, Milford, MA, USA APPLICATION BENEFITS INTRODUCTION Retention of small polar compounds…

[ APPLICATION NOTE ] The Direct Quantification of a Mutagenic Impurity, Methyl Amino Crotonate, Using ACQUITY UPC2 and QDa Detector Janet Hammond1 and Mark Wrona 2 1 Waters Corporation, Wilmslow, UK, 2 Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■■…

Application Note Pharma & Biopharma Trace Level Quantification of Potential Mutagenic Impurities in Pharmaceuticals Using an Agilent Ultivo LC/TQ with mixed mode data acquisition Authors Theresa Sosienski and Kyle Covert Agilent Technologies, Inc. Abstract This Application Note highlights an analytical…

[ APPLICATION NOTE ] Analysis of Genotoxic Impurities of Imatinib Mesylate by LC-MS from Early Development to Routine Monitoring Margaret Maziarz and Mark Wrona Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■■ ■■ ■■ INTRODUCTION Sensitive and selective UPLC® method…