The Direct Quantification of a Mutagenic Impurity, Methyl Amino Crotonate, Using ACQUITY UPC2 and QDa Detector

[ APPLICATION NOTEBOOK ] ACQUITY QDa Detector QC APPLICATIONS COMPENDIUM EDITION 2 Dear Colleague The 2013 introduction of the ACQUITY™ QDa™ Detector was a breakthrough in Chromatography and Mass Spectrometry integration. It was the fulfilment of a vision 20 years…

[ APPLICATION NOTEBOOK ] IMPURITIES Developing Safe and Effective Drugs INT RODUCTION NAVIGATION T he pharmaceutical industry is integral in maintaining public health by providing therapeutic and preventative medicines. T he cornerstones of bringing new medicines to market are quality,…

Reaction Monitoring of a Rosuvastatin Synthesis Featuring Enantiopurity Determination by ACQUITY UPC,2 ACQUITY QDa, and Trefoil Column Technology Jacob N. Fairchild1 and Michael D. Jones1,2 1 Waters Corporation, Milford, MA, USA; 2 King’s College London, London, UK A P P…

[ APPLICATION NOTE ] Analysis of Genotoxic Impurities of Imatinib Mesylate by LC-MS from Early Development to Routine Monitoring Margaret Maziarz and Mark Wrona Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■■ ■■ ■■ INTRODUCTION Sensitive and selective UPLC® method…