Lab-Scale Oligonucleotide Purification Using Waters Fraction Manager — Analytical System

[ APPLICATION NOTEBOOK ] APPLICATION SOLUTIONS FOR OLIGONUCLEOTIDES Table of Contents Introduction – UPLC Analysis of Synthetic Oligonucleotides......................................................................................................................... 4 [ HPLC & UPLC Separations ] Real-Time Analysis of RNAi Duplexes ....................................................................................................................................................................... 8 Semi-Preparative Scale Single-Stranded RNA Purification .......................................................................................................................... 11 Oligonucleotide…

[ APPLICATION NOTE ] Small Scale Peptide Isolation Using UPLC with Mass-Directed Purification Jo-Ann M. Jablonski and Andrew J. Aubin Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■■ ■■ ■■ Mass-directed small scale purification is a useful technique for isolating…

Small Scale Peptide and Impurity Isolation Using the ACQUITY UPLC H-Class and Waters Fraction Manager-Analytical Systems Jo-Ann M. Jablonski and Andrew J. Aubin Waters Corporation, Milford, MA, USA A P P L I C AT I O N B E…

Application Note Analytical Scale Isolation and Purification of Propranolol Impurities Including Nitrosamine Drug Substance Related Impurity (NDSRI) Margaret Maziarz, Paul Rainville, Stephanie Harden Waters Corporation, United States Published on Novemebr 07, 2025 Abstract Nitrosamine drug substance-related impurities (NDSRIs) are a…