Small Scale Purification of Fractions from a Complex Pharmaceutical Formulation Using the Waters Fraction Manager-Analytical and an ACQUITY Arc System

Application Note Analytical Scale Isolation and Purification of Propranolol Impurities Including Nitrosamine Drug Substance Related Impurity (NDSRI) Margaret Maziarz, Paul Rainville, Stephanie Harden Waters Corporation, United States Published on Novemebr 07, 2025 Abstract Nitrosamine drug substance-related impurities (NDSRIs) are a…

[ APPLICATION NOTE ] Small Scale Peptide Isolation Using UPLC with Mass-Directed Purification Jo-Ann M. Jablonski and Andrew J. Aubin Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■■ ■■ ■■ Mass-directed small scale purification is a useful technique for isolating…

IMPURITIES INVESTIGATION OF ARV-825 PROTEOLYSIS TARGETING CHIMERA (PROTAC) COMPOUND THROUGH FRACTION COLLECTION Authors: Margaret Maziarz, Paul Rainville Affiliations: Waters Corporation, 34 Maple Street, Milford MA 01757 Mass-directed fraction collection Forced degradation sample The ARV-825 sample was dissolved in a 45:55…

IMPURITIES INVESTIGATION OF ARV-825 PROTEOLYSIS TARGETING CHIMERA (PROTAC) COMPOUND THROUGH FRACTION COLLECTION Authors: Margaret Maziarz, Paul Rainville Affiliations: Waters Corporation, 34 Maple Street, Milford MA 01757 Mass-directed fraction collection Forced degradation sample The ARV-825 sample was dissolved in a 45:55…