Analytical Scale Isolation and Purification of Propranolol Impurities Including Nitrosamine Drug Substance Related Impurity (NDSRI)

Application Note Degradation Products of ARV-825 Proteolysis Targeting Chimera (PROTAC) Compound: Isolation and Purification Using Analytical Scale Fraction Collection Margaret Maziarz, Paul Rainville, Stephanie N Harden Waters Corporation, United States Published on July 10, 2025 Abstract Proteolysis targeting chimeras (PROTACs)…

Application Note Isolation of a Degradation Product of Ranitidine Hydrochloride Using the Waters Analytical Scale Purification System Margaret Maziarz1, Ronan Cleary1, Darcy Shave1, Stephanie Harden1, Paul D. Rainville1, Jinxia Xia1 1 Waters Corporation, United States. Published on Month XX, XXXX…

[ BROCHURE ] SUPPORTING THE CHALLENGE OF NITROSAMINE DRUG SUBSTANCE RELATED IMPURITIES ANALYSIS N-Nitrosamines are potentially mutagenic impurities that may pose a risk of cancer to humans when exposed over a prolonged period. Since 2018, global regulatory bodies have required…

[ APPLICATION NOTE ] Small Scale Purification of Fractions from a Complex Pharmaceutical Formulation Using the Waters Fraction Manager-Analytical and an ACQUITY Arc System Fadi L. Alkhateeb, Ronan Cleary, and Paul Rainville Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■■…