Impurities Investigation of ARV-825 Proteolysis Targeting Chimera (PROTAC) Compound through Fraction Collection

IMPURITIES INVESTIGATION OF ARV-825 PROTEOLYSIS TARGETING CHIMERA (PROTAC) COMPOUND THROUGH FRACTION COLLECTION Authors: Margaret Maziarz, Paul Rainville Affiliations: Waters Corporation, 34 Maple Street, Milford MA 01757 Mass-directed fraction collection Forced degradation sample The ARV-825 sample was dissolved in a 45:55…

Application Note Degradation Products of ARV-825 Proteolysis Targeting Chimera (PROTAC) Compound: Isolation and Purification Using Analytical Scale Fraction Collection Margaret Maziarz, Paul Rainville, Stephanie N Harden Waters Corporation, United States Published on July 10, 2025 Abstract Proteolysis targeting chimeras (PROTACs)…

ISOLATION OF A DEGRADATION PRODUCT OF RANITIDINE HYDROCHLORIDE USING THE WATERS ANALYTICAL SCALE PURIFICATION SYSTEM Authors: Margaret Maziarz, Ronan P. Cleary, Darcy Shave, Stephanie N. Harden, Paul D. Rainville, Jinxia Xia Affiliations: Waters Corporation, 34 Maple Street, Milford MA 01757…

[ APPLICATION NOTE ] Small Scale Purification of Fractions from a Complex Pharmaceutical Formulation Using the Waters Fraction Manager-Analytical and an ACQUITY Arc System Fadi L. Alkhateeb, Ronan Cleary, and Paul Rainville Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■■…