Noc vědy 2026 - Komunikace

Třetí den <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/cs-cz/all/events/930">27. Školy hmotnostní spektrometrie</a>, středa 23. září 2026, se dopoledne nesl ve znamení omických přístupů a metod, které posouvají možnosti běžné LC-MS analýzy. Zdeněk Spáčil otevřel program přehledem akvizičních strategií od full scanu a MS/MS přes DDA, DIA/SWATH a PRM/MRM až po HRMS, na který Jaroslava Friedecká navázala tématem společného vyhodnocování metabolomických, proteomických a lipidomických dat. Sekce „Za hranicemi rutinní MS“ pak ukázala další směry současné hmotnostní spektrometrie: Pavel Hrouzek představil využití stabilních izotopů při studiu metabolických drah, Robert Jirásko se zaměřil na iontovou mobilitu v LC/MS při analýze malých molekul a dopolední odborný blok uzavřela přednáška společnosti <a target="_blank" rel="noopener noreferrer" href="https://lcms.cz/companies/43">Shimadzu</a> věnovaná ionizační technologii <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/cs-cz/lcms/library?mainauthorItems=53&amp;search=SICRIT">SICRIT®</a>.Po intenzivním odborném programu přišlo na řadu tradiční kulturně-poznávací odpoledne. Účastníci si mohli vybrat mezi návštěvou Vyššího Brodu a tamního kláštera, výletem do Českého Krumlova spojeným s prohlídkou grafitového dolu, pěší túrou na Vítkův kámen nebo individuálním programem, jehož součástí byl také turnaj ve stolním fotbálku. Večer pak třetí konferenční den pokračoval společenským programem společnosti <a target="_blank" rel="noopener noreferrer" href="https://lcms.cz/companies/43">Shimadzu</a>, tentokrát v podobě Silent disco a tanečního večera.<h3>Program</h3><blockquote>👉<a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/program_Skola_MS_2026_final_8c8cf90056.pdf">Finální program 27. Školy MS je ke stažení zde</a></blockquote><h4>Středa, 23. 9. 2026</h4><h5>SEKCE VII. Od MS k omikám</h5><h5>08:30 – 09:15 Strategie akvizice v LC-MS: full scan vs. MS/MS, DDA vs. DIA (SWATH), PRM/MRM, HRMS&nbsp;</h5><ul><li>Zdeněk Spáčil&nbsp;</li></ul><h5>09:15 – 10:00 Kombinovaná analýza metabolomických, proteomických a lipidomických dat&nbsp;</h5><ul><li>Jaroslava Friedecká&nbsp;</li></ul><h5>10:00 – 10:30 Přestávka na kávu&nbsp;</h5><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_prestavka_na_kavu_stanek_Waters_c38a261302.jpg" alt="Škola hmotnostní spektrometrie: 27. Škola MS 2026 - den 3: Přestávka na kávu - stánek Waters" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_prestavka_na_kavu_stanek_Waters_c38a261302.jpg 208w," sizes="100vw" width="1600" height="1200"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_prestavka_na_kavu_stanek_Phenomenex_41f63e651f.jpg" alt="Škola hmotnostní spektrometrie: 27. Škola MS 2026 - den 3: Přestávka na kávu - stánek Phenomenex" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_prestavka_na_kavu_stanek_Phenomenex_41f63e651f.jpg 208w," sizes="100vw" width="1600" height="1200"><h5>SEKCE VIII. Za hranicemi rutinní MS&nbsp;</h5><h5>10:30 – 11:00 Od izotopové obálky k metabolickým drahám: využití stabilních izotopů při studiu primárního metabolismu a biosyntézy specializovaných metabolitů&nbsp;</h5><ul><li>Pavel Hrouzek&nbsp;</li></ul><h5>11:00 – 11:30 Současné techniky iontové mobility v LC/MS a jejich využití při analýze malých molekul&nbsp;</h5><ul><li>Robert Jirásko&nbsp;</li></ul><h5>11:30 – 12:00 <a target="_blank" rel="noopener noreferrer" href="https://lcms.cz/companies/43">Shimadzu</a>: SICRIT®: Nová dimenze v MS ionizaci&nbsp;</h5><ul><li>Jan Buček</li></ul><h5>12:00 – 13:30 Oběd&nbsp;</h5><h5>KULTURNĚ POZNÁVACÍ ODPOLEDNE&nbsp;</h5><ul><li>A Vyšší Brod – procházka městem, prohlídka kláštera&nbsp;</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_navsteva_klastera_b29f09e792.jpg" alt="Škola hmotnostní spektrometrie: 27. Škola MS 2026 - den 3: Vyšší Brod – procházka městem, prohlídka kláštera " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_navsteva_klastera_b29f09e792.jpg 233w," sizes="100vw" width="1600" height="1072"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_navsteva_klastera_2_a5d6ebf850.jpg" alt="Škola hmotnostní spektrometrie: 27. Škola MS 2026 - den 3: Vyšší Brod – procházka městem, prohlídka kláštera " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_navsteva_klastera_2_a5d6ebf850.jpg 208w," sizes="100vw" width="1600" height="1201"><ul><li>B Český Krumlov – prohlídka města, grafitový důl&nbsp;</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_navsteva_grafitoveho_dolu_8eb08e949b.jpg" alt="Škola hmotnostní spektrometrie: 27. Škola MS 2026 - den 3: Návštěva grafitového dolu" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_navsteva_grafitoveho_dolu_8eb08e949b.jpg 207w," sizes="100vw" width="1600" height="1210"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_prohlidka_mesta_2_0d7ca18616.jpg" alt="Škola hmotnostní spektrometrie: 27. Škola MS 2026 - den 3: Prohlídka města" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_prohlidka_mesta_2_0d7ca18616.jpg 208w," sizes="100vw" width="1600" height="1200"><ul><li>C Vítkův kámen – pěší túra&nbsp;</li><li>D Individuální program&nbsp;</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_turnaj_ve_stolnim_fotbalku_ff528cbf26.jpg" alt="Škola hmotnostní spektrometrie: 27. Škola MS 2026 - den 3: Turnaj ve stolním fotbálku" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_turnaj_ve_stolnim_fotbalku_ff528cbf26.jpg 208w," sizes="100vw" width="1600" height="1200"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_turnaj_ve_stolnim_fotbalku_2_6a7eed62ef.jpg" alt="Škola hmotnostní spektrometrie: 27. Škola MS 2026 - den 3: Turnaj ve stolním fotbálku" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_turnaj_ve_stolnim_fotbalku_2_6a7eed62ef.jpg 208w," sizes="100vw" width="1600" height="1200"><h5>19:00 – 20:30 Večeře&nbsp;</h5><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_spolecensky_vecer_fffd0d6d88.jpg" alt="Škola hmotnostní spektrometrie: 27. Škola MS 2026 - den 3: Večerní program" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_spolecensky_vecer_fffd0d6d88.jpg 208w," sizes="100vw" width="1600" height="1200"><h5>20:30 – ??? Společenský večer firmy <a target="_blank" rel="noopener noreferrer" href="https://lcms.cz/companies/43">Shimadzu</a> - Silent disco</h5><ul><li>Taneční večer</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_silent_disco_7732142c92.jpg" alt="Škola hmotnostní spektrometrie: 27. Škola MS 2026 - den 3: Společenský večer firmy Shimadzu - Silent disco" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Skola_hmotnostni_spektrometrie_27_Skola_MS_2026_den_3_silent_disco_7732142c92.jpg 245w," sizes="100vw" width="1600" height="900">

27. Škola MS 2026 - den 3

Nový grafenový inkoust pro výrobu levných a citlivých tištěných senzorů vyvinuli výzkumníci z CATRIN Univerzity Palackého ve spolupráci s kolegy z VŠB-Technické univerzity Ostrava a Univerzity Karlovy. Při přípravě inkoustu poprvé využili metodu atomárního inženýrství a díky navázaným atomům mědi jsou schopni detekovat velmi citlivě dopamin – neurotransmiter, který umožňuje přenos signálů mezi nervovými buňkami. Přístup <a target="_blank" rel="noopener noreferrer" href="https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.76796">představený v časopise Advanced Science</a> má velké šance uplatnit se v lékařské diagnostice.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CATRIN_Atom_po_atomu_Vedci_ukazali_novy_smer_v_lekarske_diagnostice_8a02ad6a66.webp" alt="CATRIN: Atom po atomu. Vědci ukázali nový směr v lékařské diagnostice" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CATRIN_Atom_po_atomu_Vedci_ukazali_novy_smer_v_lekarske_diagnostice_8a02ad6a66.webp 117w," sizes="100vw" width="1920" height="2560">Atomární inženýrství (single-atom engineering) umožňuje řídit chemickou reaktivitu materiálů na úrovni jednotlivých atomů. Jeho širšímu uplatnění v lékařské diagnostice však dosud bránil nedostatek atomárně upravených materiálů i absence na nich založených tisknutelných inkoustů.&nbsp;Nyní se vědcům podařilo vyvinout novou třídu atomárně dopovaných grafenových materiálů a také inkoust pro přípravu citlivých tištěných senzorů. Sázka na měď se vyplatila při detekci dopaminu, jehož sledování je důležité pro biomedicínský výzkum a vývoj pokročilých diagnostických technologií některých onemocnění včetně Alzheimerovy choroby.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CATRIN_Atom_po_atomu_Vedci_ukazali_novy_smer_v_lekarske_diagnostice_2_97e419f039.webp" alt="CATRIN: Atom po atomu. Vědci ukázali nový směr v lékařské diagnostice" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CATRIN_Atom_po_atomu_Vedci_ukazali_novy_smer_v_lekarske_diagnostice_2_97e419f039.webp 117w," sizes="100vw" width="1920" height="2560">„Vyvinutý NGA-Cu inkoust umožňuje výrobu plně inkoustově tištěných udržitelných papírových elektrod s velmi nízkými náklady. Samotný senzor vyžaduje pouze 1,3 mikrogramu aktivního inkoustu, stojí přibližně jednu korunu a dával stabilní odezvu minimálně po dobu tří měsíců. Inkoust je navíc plně kompatibilní s běžně dostupnými inkoustovými materiálovými tiskárnami. To vytváří velký potenciál pro přípravu cenově dostupných, digitálně navržených senzorů, jejichž funkci lze přizpůsobovat atom po atomu,“ uvedl korespondující autor článku Michal Otyepka.Základem pro novou generaci atomárních inkoustů byla dusíkem dopovaná grafenová kyselina (NGA), kterou vědci z CATRIN vyvinuli před několika lety. Nyní ji postupně obohacovali různými jednotlivými atomy kovů včetně mědi, železa nebo manganu.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CATRIN_Atom_po_atomu_Vedci_ukazali_novy_smer_v_lekarske_diagnostice_3_c15d831792.webp" alt="CATRIN: Atom po atomu. Vědci ukázali nový směr v lékařské diagnostice" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CATRIN_Atom_po_atomu_Vedci_ukazali_novy_smer_v_lekarske_diagnostice_3_c15d831792.webp 117w," sizes="100vw" width="1920" height="2560">„Ukázalo se, že elektrochemická odezva zásadně závisí na typu použitého atomu. Zatímco atomy mědi výrazně zesilují signál dopaminu, ostatní kovy jej naopak potlačují. Rozhodující&nbsp;tedy není jen samotná přítomnost izolovaných atomů kovu, ale také to, o jaký konkrétní kov se jedná. To je velmi důležitý poznatek pro další vývoj biosenzorů,“ objasnil první autor Martin-Alex Nalepa.Publikované výsledky představují novou třídu senzorických materiálů s velkým potenciálem v lékařské diagnostice. Vědci nabízí obecně využitelnou platformu pro vývoj grafenových inkoustů s jednotlivými atomy kovů a otevírají cestu ke škálovatelné, reprodukovatelné a materiálově úsporné výrobě pokročilých elektrochemických senzorů. „Jsme na začátku a fascinují nás nové možnosti, které se před námi otevírají. Vidíme, že změnou typu atomů můžeme řídit citlivost a selektivitu senzoru. Kromě dopaminu tak umíme velmi přesně stanovit například imunoglobuliny – protilátky, jejichž množství a typ mohou být důležitým ukazatelem autoimunitních nebo infekčních onemocnění,“ zdůraznil další z autorů článku Radek Zbořil.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CATRIN_Atom_po_atomu_Vedci_ukazali_novy_smer_v_lekarske_diagnostice_4_273cd760a5.webp" alt="CATRIN: Atom po atomu. Vědci ukázali nový směr v lékařské diagnostice" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CATRIN_Atom_po_atomu_Vedci_ukazali_novy_smer_v_lekarske_diagnostice_4_273cd760a5.webp 117w," sizes="100vw" width="1920" height="2560">Elektrochemické biosenzory mohou nalézt uplatnění nejen v medicíně, ale také při kontrole kvality potravin, monitorování pitné vody nebo sledování znečištění životního prostředí. Jejich klíčovou součástí jsou funkcionalizované elektrody, pro jejichž výrobu se ukázaly jako velmi vhodné materiály právě na bázi grafenu. Základem úspěchu olomouckých vědců byla cílená příprava grafenového inkoustu s potřebnými vlastnostmi.Výzkum podpořil projekt TECHSCALE z operačního programu Jan Amos Komenský.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CATRIN_Atom_po_atomu_Vedci_ukazali_novy_smer_v_lekarske_diagnostice_5_b1778f77f2.jpg" alt="CATRIN: Atom po atomu. Vědci ukázali nový směr v lékařské diagnostice: Projekt TECHSCALE (No.&nbsp;CZ.02.01.01/00/22_008/0004587) je financován z&nbsp;programu MŠMT&nbsp;OP&nbsp;JAK Špičkový výzkum, podpořeného z&nbsp;EFRR/ESF." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CATRIN_Atom_po_atomu_Vedci_ukazali_novy_smer_v_lekarske_diagnostice_5_b1778f77f2.jpg 245w," sizes="100vw" width="620" height="87"><blockquote><h4>Článek</h4><h4><a target="_blank" rel="noopener noreferrer" href="https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.76796">Single-Atom-Enhanced Fully Inkjet-Printed Electrochemical Sensor for Dopamine Detection</a></h4>Martin-Alex Nalepa, David Panáček, Vítězslav Hrubý, Matěj Jendřišák, Rostislav Langer, Michal Langer, Petr Jakubec, Ivan Dědek, Vojtěch Kupka, Michal Mazur, Radek Zbořil, Michal OtyepkaAdv. Sci., 2026, e76796<a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1002/advs.76796">https://doi.org/10.1002/advs.76796</a><h6>licencováno pod <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/">CC-BY 4.0</a></h6></blockquote>

Atom po atomu. Vědci ukázali nový směr v lékařské diagnostice

Popularizace

Věda a výzkum

Video

Článek

Nejbližší akce

Škola hmotnostní spektrometrie je odborná vzdělávací akce pořádaná od roku 1986, která vedle zajímavých přednášek a kurzů nabízí i nespočet příležitostí k přátelským setkáním a diskusím.

Škola hmotnostní spektrometrie

Český institut výzkumu a pokročilých technologií (Czech Advanced Technology and Research Institute – CATRIN) je vysokoškolský ústav Univerzity Palackého v Olomouci. Vznikl integrací vědeckých týmů Centra regionu Haná pro biotechnologický a zemědělský výzkum (CRH), Regionálního centra pokročilých technologií a materiálů (RCPTM) a Ústavu molekulární a translační medicíny (ÚMTM) s cílem úzce propojit vědecké kapacity v oblasti biomedicíny, nanotechnologií, nových materiálů, výzkumu rostlin či biotechnologií a ještě úspěšněji čelit  globálním výzvám současného světa, k nimž patří například dopady klimatických změn, boj s novými typy patogenů, diagnostika a léčba civilizačních onemocnění, odvrácení hrozící potravinové krize, získávání a ukládání „zelené“ energie, zajištění dostatku pitné vody, ochrana životního prostředí a řada dalších.

CATRIN

Noc vědců, akce oživující v jeden večer stovky vědeckých budov, do kterých se běžný smrtelník nedostane. Návštěvníci proplouvají laboratořemi, přednáškovými místnostmi, vybuchujícími experimenty a jdou do hloubky aktuálních témat. 

Noc vědců

Agilent Technologies

Technology Networks

Thermo Fisher Scientific

SelectScience

Waters Corporation

Accelerating Routine Food &amp; Beverage Testing with Optimized Methods
Explore the latest technology and methodology solutions to help you deliver results more easily and efficiently for routine Food and Beverage QC testing for : Sugars, Sugar Substitutes Additives, Vitamins and Amino Acids.
<h3>EPISODE 3 - Water and Fat Soluble Vitamines Analysis</h3>
<h3>Agenda</h3>
<h4>Develop Water and fat soluble Vitamins Analysis</h4>
<ul>
<li>Presenter: To be announced​</li>
</ul>
Abstract: Available soon
<h5>Live Q&amp;A session</h5>
<ul>
<li>Moderator: Cecile Pinto (Food &amp; Environmental Market Development Manager, South Europe - Waters)</li>
</ul>

Waters Corporation: Analysis of Water and Fat Soluble Vitamins in Food and Beverages​

Analysis of Water and Fat Soluble Vitamins in Food and Beverages​

Topics: Develop Water and fat soluble Vitamins Analysis

Water and Fat Soluble Vitamins in Food and Beverages​

Join us for this webinar series to learn and hear from experts in the field about major advancements, optimizations, and innovations of analytical technology to take your oligonucleotide analysis to the next level.
From sample to results, the analysis of oligonucleotide therapeutics requires robust and accurate analytical characterization to confirm identity, and to determine purity, quality, and strength. 
Through our external and internal expert speakers’ testimonials, you will have the chance to discover our complete workflow solutions and get a full understanding of new advancements and optimization techniques for each step of the workflow. 
Learning points:
<ul>
<li>Discover new LC-MS methods for oligonucleotide and RNA analysi
</li>
<li>Understand practical improvements and innovations in nucleic acid separations using oligonucleotide DNAPac column
</li>
<li>Find out how BioPharma Finder™ Software can support your oligonucleotide analysis.
</li>
</ul>
Who should attend:
<ul>
<li>Biopharmaceutical Research Scientists
</li>
<li>Analytical Scientists from Biopharma companies working on or interested in oligonucleotide-based therapies.
</li>
<li>PhD students in any field of biotherapeutic drug development
</li>
<li>Scientists looking to advance knowledge of oligonucleotide analysis.
</li>
</ul>
<blockquote>
Presenter: Dr. Johannes Kremser (Senior Scientist R&amp;D for Oligonucleotides, Eurofins Genomics)
</blockquote>
<blockquote>
With more than seven years of experience in the field of oligonucleotides, Dr. Johannes Kremser has a proven track record of successful project management and producing quality outcomes through professional expertise and team motivation. His advanced education began in Innsbruck at the Leopold-Franzens University where his bachelor thesis in Organic Chemistry was supervised by Univ. Prof. Ronald Micura. Upon completion of his bachelor’s degree in 2014, he continued there under the direction of Assoc. Prof. Christoph Kreutz where he defended his masters in Organic Chemistry in 2016.
</blockquote>
<blockquote>
His passion for oligonucleotide chemistry in combination with NMR spectroscopy took him abroad to London as a visiting doctoral student at the University College London where in the Department of Structural and Molecular Biology guided by Dr. D. Flemming Hansen, his project focused on RNA entitled ‘Elucidation of transiently formed excited state RNA structures by NMR spectroscopy’. With his successes in the UK, he returned in 2019 to his alma mater of Leopold-Franzens University to produce and defend his doctoral thesis “&#39;Seeing the Invisible&#39; - Investigation of RNA Excited States via NMR Spectroscopy” under supervision of Assoc. Prof. Christoph Kreutz.
</blockquote>
<blockquote>
Johannes transitioned from his academic career into his professional debut as the group leader in R&amp;D for oligonucleotides in Switzerland at Bachem AG. His subsequent and present employment with Eurofins Genomics in Ebersberg commenced in 2022 as Senior Scientist R&amp;D for Oligonucleotides where he manages the laboratory and process planning for RNA high throughput and mid-scale production and ensure ISO-conform oligonucleotide production.
</blockquote>

Thermo Scientific: Advancements & Optimization of Analytical Technology for Oligonucleotide Analysis - Webinar 1

Advancements & Optimization of Analytical Technology for Oligonucleotide Analysis - Webinar 1

Major advancements, optimizations, and innovations of analytical technology to take your oligonucleotide analysis to the next level.

Advancements & Optimization of Analytical Technology

The Cary 7000 UV-Vis-NIR system can be used to collect high quality data which can then be used to characterize optical coatings.
We will examine the techniques for determining film thickness, index of refraction, etc. through the use of a Cary 7000 UV-Vis-NIR system.
<blockquote>
Presenter: Mark Fisher, PhD (Application Engineer, Molecular Spectroscopy, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
Mark, an Application Scientist for Agilent Technologies, has over 35 years of experience in molecular spectroscopy. He has held roles in Agilent&#39;s UV-Vis-NIR, fluorescence, and atomic absorption product portfolios. In addition to identifying industry trends and new business needs, Mark&#39;s responsibilities include application development, pre and post-sales support, as well as acting as a customer advocate for new product and technology opportunities. Mark received his doctorate in analytical chemistry from the University of Nebraska-Lincoln.
</blockquote>

Agilent Technologies: Measuring and Analyzing Optical Coatings by UV-Vis-NIR

Measuring and Analyzing Optical Coatings by UV-Vis-NIR

Techniques for determining film thickness, index of refraction, etc. through the use of a Cary 7000 UV-Vis-NIR system.

Host-associated microbial communities are unique sources for natural product drug discovery.
By studying these microbes, novel and targeted drug leads can be identified and critical questions answered within the broader field of chemical ecology.
Dr. Balunas’ research connects the dots between microbes, metals and metabolites to discover new medicines for a wide range of human diseases.
In this webinar, Dr. Balunas will showcase her latest research into deriving natural products from the marine invertebrate Botryllus schlosseri.
Attend this webinar to discover:
<ul>
<li>Marine natural product drug discovery
</li>
<li>Advanced informatics tools for metabolomics
</li>
<li>Untargeted metabolomics with timsTOF
</li>
</ul>
<blockquote>
Presenter: Dr. Marcy Balunas (Associate Professor, University of Michigan)
</blockquote>

Technology Networks: Dive Into Microbes, Metals and Metabolites for Drug Discovery

Dive Into Microbes, Metals and Metabolites for Drug Discovery

Latest research into deriving natural products from the marine invertebrate Botryllus schlosseri.

Microbes, Metals and Metabolites for Drug Discovery

Critical to the development and commercialization of a biosimilar is understanding the originator and how its CQAs compare against those of the biosimilar.
Learn more about our solutions that provide high quality peptide mapping, glycan and charge variant data.
<blockquote>
Presenter: Andrew Argo (Strategic Marketing Lead, Waters Corporation)
</blockquote>
<blockquote>
Andrew has held positions across industry with a focus on analytical method development for LC and LCMS applications for products ranging from peptides to gene therapy for almost 10 years. He is currently the strategic marketing lead for the biopharma and new modality portfolios within the chemistry organization, helping to understand these evolving therapeutic areas and customer needs.
</blockquote>

Waters Corporation: Chromatographic techniques for the characterization of CQAs in biosimilars 

Chromatographic techniques for the characterization of CQAs in biosimilars

Solutions that provide high quality peptide mapping, glycan and charge variant data.

Chromatographic techniques for the characterization of CQAs

Lipidomics is a subset of metabolomics, focused specifically on the analysis of lipid species.
Lipids are among the most vital compounds in living organisms that serve to fulfil various functions, including building blocks for cellular and extracellular vesicle membranes, cell signaling, and energy storage. Studying the biological function of lipids plays a significant factor in understanding their overall effect on human health.
 The structure of a lipid can be altered, due to a shift in their environment caused by endogenous or exogenous factors. These factors can be genetics, diet-base, or caused by diseases. The classes of lipids vary in polarity, from phospholipids to triacyl glycerides, and it is estimated that there are over 300,000 possible lipid structures with varying fatty acyl chain lengths from 12 to 26 carbons. Mass spectrometry (MS)-based lipidomics generally require the use of liquid chromatography to separate the complex lipids present in biofluids, based on polarity and high-resolution MS to accurately measure the mass-to-charge (m/z).
 Join Dr. Timothy Garrett, Associate Professor at the University of Florida, to find out more about the technology needed for the correct identification of lipids, and how monodisperse particles can improve the speed and separation capacity of lipids. Plus, Garrett will also explore the analytical advances in chromatography and bioinformatics (IE-Omics), in the context of several disorders, including malaria, cancer and rare diseases.
Key learning objectives
<ul>
<li>Learn the basics of applied lipidomics using ultra-high-performance liquid chromatography- high-resolution mass spectrometry (UHPLC-HRMS/MS)
</li>
<li>Understand how lipidomics can be used for developing new diagnostic tests
</li>
<li>Discover the potential of lipidomics, while understanding current limitations
</li>
<li>Understand the role of chromatography in lipidomics
</li>
<li>Learn how utilizing monodisperse fully porous particles can improve your current lipidomics method
</li>
</ul>
Who should attend?
<ul>
<li>LC scientists that are looking for more lipidomic separations efficiency
</li>
<li>Scientists looking to improve their current HPLC/UHPLC separations for metabolomics
</li>
<li>Chromatographers looking to start developing new lipidomics based HPLC/UHPLC methods
</li>
</ul>
<blockquote>
Presenter: Timothy J. Garrett (Associate Professor, University of Florida, View Biography)
</blockquote>
<blockquote>
Dr. Timothy J. Garrett is an Associate Professor and Chief of Experimental Pathology in the Department of Pathology, Immunology and Laboratory Medicine at the College of Medicine, University of Florida. Garrett has also served as PI or Co-PI on grants and contracts totaling over $39M of funding from institutions such as the National Institutes of Health (NIH), Juvenile Diabetes Research Foundation (JDRF) and the American Diabetes Association (ADA). He has an undergraduate degree and a PhD in Chemistry. As a graduate student, he worked on the development and design the first imaging mass spectrometry ion trap instrument through a partnership with Thermo Fisher Scientific and studied the disposition and characterization of phospholipids in brain tissue. He has over 20 years of experience working with Thermo Fisher Scientific instrumentation including the TSQ 7000. He joined the faculty at the University of Florida in 2006, where he has developed a research program in metabolomics, lipidomics, and small molecule quantitation for clinical and biological research using mass spectrometry approaches. He is also currently Co-Editor-in-Chief for the Journal of Mass Spectrometry and Advances in the Clinical lab.
</blockquote>
<blockquote>
Presenter: Carrie Haslam (SelectScience)
</blockquote>
<blockquote>
Dr. Carrie Haslam is an Associate Editor at SelectScience, playing a key role in content production and specializing in Materials Science, Alzheimer’s disease and Clinical Diagnostics. Carrie completed a Ph.D. from The University of Plymouth, where she developed graphene-based biosensors for the early diagnosis of Alzheimer’s disease.
</blockquote>

SelectScience: Mass spectrometry-based lipodomics using monodisperse particle UHPLC/HPLC (MFPP) columns for biomarker discovery

Mass spectrometry-based lipodomics using monodisperse particle UHPLC/HPLC (MFPP) columns for biomarker discovery

Technology needed for the correct identification of lipids, and how monodisperse particles can improve the speed and separation capacity of lipids.

Mass spectrometry-based lipodomics & MFPP columns

N-nitrosamines are potential carcinogenic impurities that can pose a risk to human health when exposed over an extended period.
Whilst global regulations are evolving, where there is risk of N-nitrosamine formation in drug products, analytical testing is still necessary. With this continues a requirement for customized and optimized sample extraction, chromatographic separation, and often flexible mass spectrometry acquisition, supporting a range of regulatory set threshold limits, for both small and complex N-nitrosamines.
Small and complex N-nitrosamines (NDSRI) present common challenges, such as extraction efficiency and robust detection, whether quantification is to the trace level or to higher limits of sensitivity. Specific challenges also arise, such as minimizing low mass interference for small N-nitrosamines or managing structural similarities to the API and isomeric separation for NDSRIs. Minimizing contamination and N-nitrosamine formation during sample preparation is always critical.
In this webinar, Dr. Padmakar Wagh, Associate Director: Applications at Waters Corporation and Hugo Cortés, a senior specialist in mass spectrometry at Waters Corporation, will demonstrate strategies for developing robust quantification assays for both small N-nitrosamines and NDSRI in drug products. They will address the typical challenges encountered for both types of N-nitrosamines, and will include practical examples of quality method development and take-away method development strategies from Waters laboratories.
Key learning objectives
<ul>
<li>Understand the common and specific challenges in developing quantitation methods for small and complex (NDSRI) N-nitrosamines
</li>
<li>Discover new strategies for optimizing the sensitivity of N-nitrosamines detection in drug products by LC-MS
</li>
<li>Learn how to manage selectivity challenges in sample extraction and chromatography separation of small and complex N-nitrosamines
</li>
<li>Explore tools to increase efficiency and confidence in N-nitrosamines method development
</li>
</ul>
Who should attend?
Analytical development laboratories and QC laboratories in the innovative and generic pharmaceutical industry, contract testing, and contract manufacturing to the pharmaceutical industry, laboratory managers, and senior scientists.
<blockquote>
Presenter: Dr. Padmakar Wagh (Waters Corporation)
</blockquote>
<blockquote>
Dr. Padmakar Wagh has been working in his present role as Associate Director: Applications at Waters Corporation for the past 6 years. He has been responsible for managing Waters demo labs across India and has been actively involved in developing various applications including nitrosamines. Before joining Waters, he worked at various pharmaceutical companies in analytical research and development. He has a PhD in chromatography and is passionate about solving analytical challenges. He is also one of the founder members of a charitable hospital which serves the needy in the rural areas of India.
</blockquote>
<blockquote>
Presenter: Hugo Cortés (Waters Corporation)
</blockquote>
<blockquote>
Hugo Cortés is a senior specialist in mass spectrometry at Waters Corporation, a position he has held for 11 years. He attended the National Polytechnic Institute College of Biomedical Sciences in Mexico where he studied biochemical engineering. He has worked in analytical development in pharmaceutical, environmental, food safety, natural products research, metabolomics and toxicological analysis areas with Waters products for 20 years. He has participated in the development of methods for the analysis of nitrosamine together with regulatory entities in Mexico for four years.
</blockquote>
<blockquote>
Presenter: Ellen Simms (Assistant Editor, SelectScience)
</blockquote>
<blockquote>
Ellen studied biological sciences at the University of the West of England, UK, before completing a master&#39;s in epidemiology from the University of Bristol. As a member of the Editorial team, she now plays an integral role in shaping the content on SelectScience.
</blockquote>

SelectScience: Optimized method development strategies for the quantification of small and complex N-nitrosamines impurities

Optimized method development strategies for the quantification of small and complex N-nitrosamines impurities

Strategies for developing robust quantification assays for both small N-nitrosamines and NDSRI in drug products.

Optimized method development strategies

The increased production demand for oligonucleotides has led to a need for faster characterization tools that ensure product quality and designated effect.
Join Dr. Thomas Walker, LC/MS Applications Scientist at Agilent Technologies, as he presents a complete, automated, high-throughput workflow for characterization, data processing, and report generation for oligonucleotides. Explore how the RapidFire 400 enables mass spec data acquisition of oligo samples in less than 15 seconds per sample.
Key learning objectives
<ul>
<li>Understand RapidFire’s utility in high throughput applications
</li>
<li>Discover how BioConfirm software is used to analyze oligo data
</li>
<li>Explore how BioMS Reviewer simplifies report generation and data presentation
</li>
</ul>
Who should attend?
<ul>
<li>Anyone interested in mass spectrometry analysis of oligos and high-throughput mass spectrometry</li>
</ul>
<blockquote>
Presenter: Thomas E. Walker, PhD (LC/MS Application Scientist, Agilent Technologies)
</blockquote>
<blockquote>
Dr. Thomas Walker graduated from Texas A&amp;M University where he specialized in mass spectrometry instrumentation design and application development. He works at the Agilent Lexington, MA site as an LC/MS Application Scientist specializing in protein and oligo applications using TOF, QTOF, IM-QTOF, and RapidFire. He has also contributed to the implementation of a complete, automated workflow for oligo impurity analysis using RapidFire-MS.
</blockquote>
<blockquote>
Presenter: Jemima Arnold (Editorial Assistant, SelectScience)
</blockquote>
<blockquote>
Jemima studied Cellular and Molecular Medicine at the University of Bristol, UK, and as a member of the Editorial team, she now plays an integral role in shaping the content on SelectScience.
</blockquote>

LabRulez/AI: Oligonucleotide Screening By Automated High-Throughput Mass Spec: Maximizing Speed and Confidence

Oligonucleotide Screening By Automated High-Throughput Mass Spec: Maximizing Speed and Confidence

Complete, automated, high-throughput workflow for characterization, data processing, and report generation for oligonucleotides.

Maximizing Speed and Confidence

Amino Acid Analysis is required in many applications related to foods, dietary supplements and animal feeds and is a fundamental tool for monitoring product QC and compliance with nutritional labeling.
AOAC International has recently published a standardized method (AOAC Official Method 2018.06) for the analysis of total amino acids in infant formulas and adult nutritionals by UHPLC-UV. For some samples, to obtain a full amino acid profile, the samples must first be hydrolyzed. Due to the varied properties of amino acids and diversity of sample matrices, hydrolysis, separation and detection represents an analytical challenge. Learn more about effective hydrolysis, separation and detection of amino acids in dietary supplements, plant-based meats, and pet food during a 3-part webinar series with CEM and Waters.
<blockquote>
Presenter: Alicia Douglas Stell, Ph.D. (Market Development Manager, Applied Markets, CEM Corporation)
</blockquote>
<blockquote>
Dr. Alicia Douglas Stell has worked with CEM for the past 15 years, joining after completing her PhD in Analytical Chemistry. Her extensive background in chromatographic analysis and her mechanical expertise have been integral in the development of both instrumentation and novel applications. In her role as Market Development Manager, she is continuously exploring new applications and markets for innovative technology, focused around sample preparation.
</blockquote>
<blockquote>
Presenter: Benedict Liu (Product Specialist, Organic Solutions, CEM Corporation)
</blockquote>
<blockquote>
Benedict Liu graduated from UNC Chapel Hill in 2018 with a bachelor&#39;s degree in chemistry and mathematics. He joined CEM soon after and has been with the company for 5 years serving as an applications chemist and product specialist for the Molecular Sample Preparation division. In his time at CEM, Ben has worked to develop solutions for the extraction of organic pollutants in soils and product, microwave amino acid hydrolysis protocols, and automated extraction methods for PFAS in solid and semi-solid matrices.
</blockquote>
<blockquote>
Presenter: Paula Phenix (Principal Product Marketing Manager, Waters Corporation)
</blockquote>
<blockquote>
Paula is a Principal Product Marketing Manager at Waters with a focus on products for amino acid and glycan analysis. Prior to her current role in the Chemistry and Lab Automation Group, she was the Product Marketing Manager for Specialty LC and SFC Systems in the Instruments group. Before joining Waters, she held product management, marketing and sales roles for several companies (Life Technologies, Promega, MilliporeSigma) in the molecular biology, immunology, cell culture and single-use bioprocessing areas. Paula graduated from the University of Delaware with a Bachelor’s degree in Biology and from Johns Hopkins University with a Master’s degree in Business.
</blockquote>
<blockquote>
Presenter: Ravali Alagandula, Ph.D. (Chemistry Market Development Manager, Waters Corporation)
</blockquote>
<blockquote>
Ravali is a Chemistry Market Development Manager at Waters with focus on all chemistry consumables and lab automation products. She holds a Ph. D. in Analytical Chemistry from Cleveland State University. She started her career as an LC applications scientist at Restek, developing LC-MS/MS and sample preparation methods in clinical and life science markets. Most recently, Ravali was a Chemistry Account Manager at Waters supporting key accounts and customers to promote chemistry consumable business in all market areas.
</blockquote>

Waters Corporation: Easy & Efficient Amino Acid Sample Prep followed by Accurate Detection - a look at Wet and Dry Pet Food

Easy & Efficient Amino Acid Sample Prep followed by Accurate Detection - a look at Wet and Dry Pet Food

Learn more about effective hydrolysis, separation and detection of amino acids in dietary supplements, plant-based meats, and pet food.

A look at Wet and Dry Pet Food

Besides being the major provider for genotyping and DNA sequencing services, Eurofins Genomics Europe Pharma and Diagnostic Products &amp; Services Synthesis GmbH is one of the world-leading oligonucleotide manufacturers for the industrial and research sector.
Since 2021, Eurofins Genomics can capitalise of next generation high throughput synthesizers, the so-called Continuous Flow Synthesizer (CFS), which allow a simultaneous production of 6 x 384 different oligonucleotides with elevated speed reaching an excellent coupling efficiency of up to 99.6%.
We present an elaborated upstream and downstream process for the high throughput production of standard and modified oligonucleotides of a length up to 200 nucleotides, including insights into the chemical background. Beside the synthesis procedure, the sample purification and analysis are the major hurdles in oligonucleotide production. The Thermo Scientific™ Vanquish™ IP-RP-UPLC, commonly used with customary C18 columns to obtain highly resolved analytical chromatograms for an unambiguous sample composition determination, was proven to be very suitable for semi-preparative purification applications for oligonucleotides like dual-labeled probes. In addition, we showcase the crucial role of LC-ESI-MS investigation on a modified DNA longmer leading to an optimized production strategy and hence resulting in a significantly improved impurity profile which massively simplifies the subsequent chromatographic purification.
Learning points:
<ul>
<li>Discover an upstream and downstream process for the high throughput production of standard and modified oligonucleotides of a length up to 200 nucleotides.
</li>
<li>Learn how to overcome challenges regarding sample purification and analysis.
</li>
<li>Learn about the crucial role of LC-ESI-MS investigation on a modified DNA longmer leading to an optimized production strategy
</li>
</ul>
Who should attend:
<ul>
<li>Biopharmaceutical Research Scientists 
</li>
<li>Analytical Scientists from Biopharma companies working on or interested in oligonucleotide-based therapies. 
</li>
<li>PhD students in any field of biotherapeutic drug development
</li>
<li>Scientists looking to advance knowledge of oligonucleotide analysis.
</li>
</ul>
<blockquote>
Presenter: Dr. Johannes Kremser (Senior Scientist R&amp;D for Oligonucleotides, Eurofins Genomics)
</blockquote>
<blockquote>
With more than seven years of experience in the field of oligonucleotides, Dr. Johannes Kremser has a proven track record of successful project management and producing quality outcomes through professional expertise and team motivation. His advanced education began in Innsbruck at the Leopold-Franzens University where his bachelor thesis in Organic Chemistry was supervised by Univ. Prof. Ronald Micura. Upon completion of his bachelor’s degree in 2014, he continued there under the direction of Assoc. Prof. Christoph Kreutz where he defended his masters in Organic Chemistry in 2016.
</blockquote>
<blockquote>
His passion for oligonucleotide chemistry in combination with NMR spectroscopy took him abroad to London as a visiting doctoral student at the University College London where in the Department of Structural and Molecular Biology guided by Dr. D. Flemming Hansen, his project focused on RNA entitled ‘Elucidation of transiently formed excited state RNA structures by NMR spectroscopy’. With his successes in the UK, he returned in 2019 to his alma mater of Leopold-Franzens University to produce and defend his doctoral thesis “&#39;Seeing the Invisible&#39; - Investigation of RNA Excited States via NMR Spectroscopy” under supervision of Assoc. Prof. Christoph Kreutz.
</blockquote>
<blockquote>
Johannes transitioned from his academic career into his professional debut as the group leader in R&amp;D for oligonucleotides in Switzerland at Bachem AG. His subsequent and present employment with Eurofins Genomics in Ebersberg commenced in 2022 as Senior Scientist R&amp;D for Oligonucleotides where he manages the laboratory and process planning for RNA high throughput and mid-scale production and ensure ISO-conform oligonucleotide production.
</blockquote>
<blockquote>
Presenter: Dennis Köhler (Product Application Specialist, Thermo Fisher Scientific)
</blockquote>
<blockquote>
Dennis Köhler has a pronounced career ranging from organic synthesis in the field of oligonucleotides as well as analytics for almost 2 decades. Graduating from the University of California, San Diego in 2004 he immediately initiated his professional path in the region of modified nTP synthesis and purification at Trilink Biotechnologies, Inc. Subsequently, he spent short of 10 years synthesizing fluorophores for DNA labelled FRET technologies for Biosearch Technologies, Inc. After moving to Vienna in 2014, he joined the Thermo Scientific team as sales support for chromatography where in 2018 he transitioned to the Thermo Scientific Product Applications team outside of Munich, contributing to application notes, collaborations, new product development, and elevated field support.
</blockquote>

Thermo Scientific: Towards the high throughput production of oligonucleotides – Insights into upstream, downstream and analysis

Towards the high throughput production of oligonucleotides – Insights into upstream, downstream and analysis

Elaborated upstream and downstream process for the high throughput production of standard and modified oligonucleotides of a length up to 200 nucleotides.