Online IEX-MS Characterization and Monitoring of mAb Charge Heterogeneity Using an Optimized Cation Exchange Resin and Compact TOF Mass Spectrometer

ONLINE IEX-MS CHARACTERIZATION AND MONITORING OF MAB CHARGE HETEROGENEITY USING AN OPTIMIZED CATION EXCHANGE RESIN AND COMPACT TOF MASS SPECTROMETER Samantha Ippoliti1, Qi Wang1, Ying Qing Yu1, Matthew A. Lauber1, Henry Shion1 1 Waters Corporation, Milford, MA, USA IdeS-Digested Trastuzumab…

Characterization and Monitoring of mAb Charge Variants via Online IEX-MS Samantha Ippoliti Waters MS User Meeting ASMS 2019 Atlanta, GA June 1, 2019 ©2019 Waters Corporation 1 Agenda 1. mAb CQA Characterization 2. Reverse Phase vs Ion Exchange Chromatography 3.…

[ APPLICATION NOTE ] Online IEX-MS of mAb Charge Variants Using a BioResolve SCX mAb Column, IonHance CX-MS pH Concentrates, and BioAccord System Samantha Ippoliti, Andrew Schmudlach, Matthew A. Lauber, and Ying Qing Yu Waters Corporation, Milford, MA, USA APPLICATION…

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