ACQUISITION MODE CHARACTERIZATION FOR THE QUANTITATIVE AND QUALITATIVE ANALYSIS OF CROSS-LINKED PEPTIDES BY TARGETED AND UNTARGETED LC-IM-MS

Thermo Scientific™ Proteome Discoverer™ using a XlinkX software node. Methods: Different amine-reactive, homobifuctional crosslinkers including disuccinimidyl Results: For both DSSO and BuUrBu, we identified over 40 BSA inter-crosslinked peptides 2 CID for DSSO. We also to less than(DSS), 20 using…

proteomics WHITE PAPER 65343 Crosslinking mass spectrometry (XL-MS) goes mainstream Mass spectrometrists and structural biologists guide to using XL-MS to understand the structure and function of molecular machines Author Executive summary Julian Saba, Thermo Fisher Scientific, San Jose, CA, USA…

LC separation optimization for XL-MS Analysis Yi He1, Erum Raja2, Leigh Foster2, Max Ruwolt3, Anthony Ciancone4, Fan Liu3, Francis O’Reilly4, Ryan Bomgarden2, Rosa Viner1 1Thermo Fisher Scientific, San Jose, CA, USA; 2Thermo Fisher Scientific, Rockford, Illinois, USA; 3Department of Structural…

up le Sca your structural analysis Orbitrap Ascend Structural Biology Tribrid mass spectrometer Scale up insight from complex native structures Unlock the intricacies of complex molecular structures Built to meet the demands of structural biology, the Thermo Scientific™ Orbitrap™ Ascend…