Precise Quantitative Serum LC-MS/MS Profiling: The Impact of Sample Preparation and Sample Source on Biomarker Discovery Studies

Plasma proteomics goes high throughput – timsTOF Pro with PASEF and 4D feature alignment to quantify 500 plasma proteins in 11.5 min The timsTOF Pro with PASEF and the Evosep One for biomarker discovery in large sample cohorts of human…

APPLICATION NOTE No. 73194 High-throughput plasma proteomics: A standardized and scalable workflow for quantitative protein profiling in large sample cohorts Keywords Q Exactive, Orbitrap, protein biomarker, plasma workflow, serum workflow, Evosep, high throughput proteomics workflow Authors Jing Wang1; Sarah Trusiak1;…

Application Note Highlights Unlocking the plasma proteome with Evotip Pure based, standardized and scalable workflows Fully automated, end-to-end workflow for neat and deep plasma profiling Standardized and cost-efficient strategy to monitor disease at scale 1. Introduction Plasma stands out as…

CASE STUDY 66002 Orbitrap Exploris 240 mass spectrometer delivers significantly increased lab productivity and reproducibility of human plasma proteome profiling from large human cohort studies “For large clinical cohort studies where hundreds of plasma samples are to be analyzed, a…