Multimodal Chemical Imaging to probe Alzheimer’s Disease Pathology

Multimodal Chemical Imaging to probe Alzheimer’s Disease Pathology MALDI Imaging has emerged as a valuable tool for understanding neurodegenerative pathology in Alzheimer’s disease. Abstract Already affecting 12% of population over the age of 65, and with an exponential increase in…

LI F E S CI E N CE S M AS S S P E CTR O M E TR Y Exploring the Aβ Plaque microenvironment in Alzheimer's disease model mice by multimodal Lipid-Protein-Histology Imaging on a benchtop mass spectrometer…

Poster: ThP 552 Abstract: 312475 A Novel 3D Imaging Pipeline for Analyzing Efficacy of Compounds on Amyloid-Beta Plaque Dynamics in Pre-clinical Alzheimer’s Disease Animal Models Gianna Ferron1, Anthony Knesis1, Stefan Linehan1, Tim Ragan1, Michael Sasner2, Katherine Stumpo3, Michael Easterling3, Mark…

RNA Oxidation Adducts 8-OHG and 8-OHA Change with Ab42 Levels in Late-Stage Alzheimer’s Disease Adam M. Weidner1,2., Melissa A. Bradley1,2., Tina L. Beckett1., Dana M. Niedowicz1,2, Amy L. S. Dowling1,4, Sergey V. Matveev1, Harry LeVine III1,2, Mark A. Lovell1,3*, M.…