A Novel 3D Imaging Pipeline for Analyzing Efficacy of Compounds on Amyloid-Beta Plaque Dynamics in Pre-clinical Alzheimer’s Disease Animal Models

LI F E S CI E N CE S M AS S S P E CTR O M E TR Y Exploring the Aβ Plaque microenvironment in Alzheimer's disease model mice by multimodal Lipid-Protein-Histology Imaging on a benchtop mass spectrometer…

Application Note No. 81 Rapid Mapping of Imipramine, Chloroquine, and Their Metabolites in Mouse Kidneys and Brains Using the iMScopeTM QT Ariful Islam1, Takumi Sakamoto1, Qing Zhai1, Md. Muedur Rahman1, Md. Al Mamun1, Yutaka Takahashi1,2, Tomoaki Kahyo1,2, and Mitsutoshi Setou1,…

Application Note No. 68 Enzyme Histochemistry Using Mass Spectrometry Imaging Shuichi Shimma1, 2, 3, Emi Takeo1, Kaoru Nakagawa, Takushi Yamamoto, and Eiichiro Fukusaki1, 2, 3 Life Science Life Science  Abstract enzyme activity on the surface of tissue sections, it…

Multimodal Chemical Imaging to probe Alzheimer’s Disease Pathology MALDI Imaging has emerged as a valuable tool for understanding neurodegenerative pathology in Alzheimer’s disease. Abstract Already affecting 12% of population over the age of 65, and with an exponential increase in…