Accurate and reliable quantitation of p-toluenesulfonates genotoxic impurities in an active pharmaceutical ingredient by HPLC-UV

APPLICATION BRIEF 73116 Accurate and reliable quantitation of p-toluenesulfonates genotoxic impurities in an active pharmaceutical ingredient by HPLC-UV Authors Sylvia Grosse, Mauro De Pra, Frank Steiner Thermo Fisher Scientific, Germering, Germany Keywords Genotoxic impurities, p-toluenesulfonates, active pharmaceutical ingredient, aprepitant, UV…

APPLICATION NOTE 72976 Identity confirmation and accurate quantitation of a genotoxic impurity in an active pharmaceutical ingredient by UHPLC-UV coupled to a single quadrupole mass detector Authors Sylvia Grosse, Mauro De Pra, Frank Steiner Thermo Fisher Scientific, Germering, Germany Application…

APPLICATION NOTE 72976 Identity confirmation and accurate quantitation of a genotoxic impurity in an active pharmaceutical ingredient by UHPLC-UV coupled to a single quadrupole mass detector Authors Sylvia Grosse, Mauro De Pra, Frank Steiner Thermo Fisher Scientific, Germering, Germany Application…

LAAN-J-MS-E018B GCMS Gas Chromatograph Mass Spectrometer Analysis of Potential Genotoxic Impurities in Active Pharmaceutical Ingredients 18B Chemicals such as methanesulfonic acid (mesylate), benzenesulfonic acid (besilate), and p-toluenesulfonic acid (tosylate) are used in the process of synthesizing active pharmaceutical ingredients. These…