Identity confirmation and accurate quantitation of a genotoxic impurity in an active pharmaceutical ingredient by UHPLC-UV coupled to a single quadrupole mass detector

APPLICATION NOTE 72976 Identity confirmation and accurate quantitation of a genotoxic impurity in an active pharmaceutical ingredient by UHPLC-UV coupled to a single quadrupole mass detector Authors Sylvia Grosse, Mauro De Pra, Frank Steiner Thermo Fisher Scientific, Germering, Germany Application…

APPLICATION BRIEF 73116 Accurate and reliable quantitation of p-toluenesulfonates genotoxic impurities in an active pharmaceutical ingredient by HPLC-UV Authors Sylvia Grosse, Mauro De Pra, Frank Steiner Thermo Fisher Scientific, Germering, Germany Keywords Genotoxic impurities, p-toluenesulfonates, active pharmaceutical ingredient, aprepitant, UV…

APPLICATION BRIEF 73116 Accurate and reliable quantitation of p-toluenesulfonates genotoxic impurities in an active pharmaceutical ingredient by HPLC-UV Authors Sylvia Grosse, Mauro De Pra, Frank Steiner Thermo Fisher Scientific, Germering, Germany Keywords Genotoxic impurities, p-toluenesulfonates, active pharmaceutical ingredient, aprepitant, UV…

Coupling Mass Detection with UV to Improve Method Sensitivity for Esters of Benzenesulfonic Acid in Analysis of Genotoxic Impurities Margaret Maziarz and Mark Wrona Waters Corporation, Milford, MA, USA A P P L I C AT I O N B…