Multi-Attribute Analysis of Monoclonal Antibodies Using the Agilent InfinityLab 2D-LC Solution and Q-TOF MS

Biopharma Compendium Accelerate Your CQA Efficiency and Approach it with Multi-Attribute Methodology Breakthroughs to Increase the Efficiency of Critical Quality Attribute (CQA) Testing and Allow for a Multi- Attribute Method (MAM) Production of therapeutic monoclonal antibodies (mAbs) relies on living…

Application Note Biopharma/Pharma Determination of Multiple Attributes of Monoclonal Antibodies Simultaneous and parallel multi-attribute analysis using 3D-LC/MS with 2D multimethod option mAb SEC Size variants Protein A CEX LC/MS mAb Titer Charge variants Mol wt (MW) AA sequence PTM Cell…

MULTIDIMENSIONAL LC-MS PLATFORMS FOR STRUCTURE-FUNCTION CHARACTERIZATION OF THERAPEUTIC ANTIBODIES Jelle De Vos The Multidimensional Chromatography Workshop 2025, Liège 4 February 2025 The wonders of nature! RNA Protein DNA Cell 2 Monoclonal antibodies (mAbs) EVQLVESGGGLVQPGGSLRLSCAAS GFNIKDTYIHWVRQAPGKGLEW-- l mAbs have become a…

Agilent AdvanceBio Desalting-RP Cartridges for Online Desalting in 2D‑LC/MS mAb Analysis Application Note Biotherapeutics and Biologics Authors Abstract Suresh Babu C.V. and Ravindra Gudihal This Application Note describes the use of a desalting cartridge in the second Agilent Technologies, Inc.…