Streamlined Characterization of Recombinant AAVs via Charge Detection Mass Spectrometry: Insights from the USP AAV8 Reference Standards

A Streamlined Workflow for the Characterisation and Relative Quantification of Recombinant Adeno-Associated Viruses using Charge Detection Mass Spectrometry Anisha Haris1, David Eatough1, Rebecca J D’Esposito2, Andrew Tudor1, Edvinas Karmonas1, David Bruton1, Keith Richardson1, Jakub Ujma1, Chris Wheeldon1, Alistair Schofield1, Michael…

Customer note | 001049 Biotechnology Quantitative analysis of genome packaging in adeno-associated viruses using native MS Authors Key benefits Lisa Strasser1*, Tomos E. Morgan1, Felipe • Intact native mass spectrometry (MS) for the analysis of AAV-based viral vectors does not…

Characterizing Nucleic Acid Payloads in Lipid Nanoparticles and Viral Vectors via Charge Detection Mass Spectrometry (CDMS) Rebecca J. D'Esposito1; Alexandre Gomes1, Emily Christofi2; Ying Qing Yu1; Michelle Chen3 1Waters Corporation, Milford, MA; 2Waters Corporation, Wilmslow, United Kingdom; 3Waters Corporation, Goleta,…

Determination of Full, Partial and Empty Capsid Ratios for Adeno-Associated Virus (AAV) Analysis Tingting Li, Tie Gao, Hongxu Chen, Zuzana Demianova, Fang Wang, Mukesh Malik, Jane Luo, Handy Yowanto, Sahana Mollah SCIEX, Brea, CA Introduction Adeno-associated virus (AAV) is one…