Determination of Fatty Acids Composition in Polysorbates 80 and 20 Pharmaceutical Raw Materials by HPLC with Mass Detection

QUALITY ASSESSMENT OF POLYSORBATES 80 AND 20 PHARMACEUTICAL RAW MATERIALS BY MEASURING FATTY ACIDS COMPOSITION USING HPLC WITH MASS DETECTION Authors: Margaret Maziarz, Paul Rainville, Isabelle VuTrieu, Andrew Leightner Affiliations: Waters Corporation, Milford, MA The U.S. Pharmacopoeia specifies a gas…

DETERMINATION OF FATTY ACIDS COMPOSITION IN POLYSORBATES 80 AND 20 PHARMACEUTICAL RAW MATERIALS BY HPLC WITH MASS DETECTION Authors: Margaret Maziarz, Paul Rainville Affiliations: Waters Corporation, Milford, MA, USA 100% water INTRODUCTION 1 M NaOH Intensity 0 0 1 M…

Quality assessment of Polysorbates 80 and 20 Pharmaceutical Raw Materials by Measuring Fatty Acids Composition using HPLC with Mass Detection M123008-52 Margaret Maziarz, Paul Rainville Waters Corporation, 34 Maple Street, Milford MA CONTACT INFORMATION: [email protected], [email protected] PURPOSE Polysorbates are non-ionic…

Analysis of Fatty Acids in Polysorbate 80 Using High-Performance Liquid Chromatography (HPLC) with Charged Aerosol Detection (CAD) Authors: Margaret Maziarz, Stephanie Harden, Paul Rainville, Jinchuan Yang Affiliations: Waters Corporation, Milford, United States Limit of quantitation (LOQ) LOQ were determined based…