Quantitation of Nicotine, Cotinine and 3-OH-trans-cotinine in urine using LC-MS/MS with a dilute-and-shoot method approach

J. Jones, Thermo Fisher Scientific, Runcorn, Cheshire, UK Key Words SPE, SOLA CX, Syncronis C18, nicotine, cotinine, trans-3-hydroxycotinine Abstract A liquid chromatography tandem mass spectrometry method for nicotine, cotinine, and trans-3-hydroxycotinine in urine has been developed. Using Thermo Scientific™ SOLA™…

APPLICATION Shimadzu News 1/2005 APPLICATION Shimadzu News 1/2005 Optimal efficiency and flexibility in drug tests Dual Column GCMS- QP2010 THCCOOH Within-day VC % Between-day VC % Accuracy (Bias %) 35 ng/mL 150 ng/mL 400 ng/mL 9.02 13.75 -2.26 7.07 5.72…

J. Jones, Thermo Fisher Scientific, Runcorn, Cheshire, UK Key Words SPE, SOLA CX, Syncronis C18, nicotine, cotinine, trans-3-hydroxycotinine Abstract A liquid chromatography tandem mass spectrometry method for nicotine, cotinine, and trans-3-hydroxycotinine in urine has been developed. Using Thermo Scientific™ SOLA™…

Application Note No. 012 The measurement of low levels of Cotinine in Saliva. B E Frost and D J Tuck, Rothmans International Services Ltd, Basildon, Essex Introduction Nicotine is metabolised in the body to cotinine and other metabolites such as…