Complete characterization of KADCYLA using a new Orbitrap Excedion Pro BioPharma hybrid mass spectrometer with electron-transfer/higher-energy collision dissociation (EThcD) fragmentation

APPLICATION NOTE 72511 Complete characterization of a lysine-linked antibody drug conjugate by native LC/MS intact mass analysis and peptide mapping Authors Aaron O. Bailey,1 Stephane Houel,1 Kai Scheffler,2 Eugen Damoc,3 Jennifer Sutton,1 Jonathan L. Josephs1 Thermo Fisher Scientific 1 San…

In-depth peptide mapping of biopharmaceuticals using an electron-transfer/higher-energy collision dissociation (EThcD) implemented on a modified Orbitrap hybrid MS Reiko Kiyonami1, Cong Wang2, Peter Krueger2, Roberto Gamez1, Heiner Koch2, Min Du1 1Thermo Fisher Scientific, Lexington, MA; 2Thermo Fisher Scientific, Bremen, Germany…

Complete Characterization of Trastuzumab Deruxtecan, a Cysteine-linked antibody drug conjugate, using high resolution accurate mass (HRAM) Mass Spectrometry Xiaoxi Zhang1, Min Du2, 1 Thermo Fisher Scientific, Shanghai, China; 2 Thermo Fisher Scientific, Lexington, Massachusetts, US Abstract Results Purpose: To demonstrate…

Mass spectrometry Discover. Innovate. Exceed. Orbitrap Excedion Pro Mass Spectrometers Discover. Innovate. Exceed. Welcome to the next generation of mass spectrometry with Thermo Scientific™ Orbitrap™ Excedion™ Pro hybrid mass spectrometers (MS). Building on our outstanding legacy quadrupole-Orbitrap mass spectrometry technology,…