Enhancing MRNA Production Quality: Comprehensive Charge Detection Mass Spectrometry (CDMS) Analysis of DNA Plasmid and MRNA Structures

Application Note Slalom-Aided Anion Exchange Chromatography for Enhanced Analysis of Plasmid DNA Topological Impurities Abraham S. Finny, Fabrice Gritti, Szabolcs Fekete, Balasubrahmanyam Addepalli, Matthew A. Lauber Waters Corporation, United States Published on July 23, 2025 Abstract Slalom-Aided Anion Exchange Chromatography…

Application Note Plasmid Topology and Digest Analysis Using a GTxResolve™ 250 Å Slalom Chromatography Column Jamuna Vaishnav, Balasubrahmanyam Addepalli, Matthew A. Lauber Waters Corporation, United States Published on August 18, 2025 Abstract This application note illustrates the characterization of plasmid…

Simple, Fast and Robust Method for Plasmid Purity Testing and Degradation Monitoring Capillary Electrophoresis-Laser Induced Fluorescence Detection (CE-LIF) Jane Luo, Tingting Li, and Mukesh Malik SCIEX, Brea, California A Introduction Plasmid DNA is often used as the gene delivery vehicle…

Gene Therapy and Oligonucleotide Compendium Volume 1 Gene Therapy and Oligonucleotide Compendium Contents Introduction 4 Growing trends and emerging technologies for oligonucleotide and gene therapies 6 The global gene therapy & oligonucleotide market 8 Regional landscape North America EMEAI (Europe,…