Integrated MALDI-MSI and Glycopeptide LC-MS/MS Reveal Site-and Region-Specific Glycosylation Changes in Tumor Tissue

MALDI FTMS Imaging Mass Spectrometry of N-glycans as Tissue Biomarkers of Cancer In this application note, we describe preparation and imaging analysis of N-glycans from formalin-fixed paraffin embedded (FFPE) tissues using the solariX MALDI FTMS. N-glycosylation is a common post…

MALDI-2 for enhanced in situ N-glycan analysis N-glycans are important players in a variety of pathologies including different types of cancer, (auto)immune diseases, and also viral infections. Abstract Matrix-assisted laser desorption/ ionization mass spectrometry (MALDI-MS) is an important tool for…

Integrated mass spectrometry-based analysis of plasma glycoproteins and their glycan modifications ASMS 2011 ThP629 Hong Wang1,2, Chee-Hong Wong1, Alice Chin1, Ayumu Taguchi1, Allen Taylor1, Samir Hanash1, Sadanori Sekiya3, Hidenori Takahashi3, Masaki Murase3, Shigeki Kajihara3, Shinichi Iwamoto3, Koichi Tanaka3 1 Fred…

Deanna Hurum, Lipika Basumallick, and Jeffrey Rohrer Thermo Fisher Scientific, Sunnyvale, CA, USA Key Words Prostate-Specific Antigen (PSA), Transferrin, N-Glycans, O-Glycans, Dionex CarboPac Column Introduction Changes in protein glycosylation are frequently studied in cancer research to identify potential biomarkers. Factors…