Analysis of Underivatized Bisphosphonate Drugs Using HILIC-MS

Application Note LC-MS Analysis of Underivatized Bisphosphonate Drugs Using Mixed-Mode Reversed-Phase/Anion-Exchange Chromatography Melissa L. Aiello, Kenneth D. Berthelette, Christopher Collins, Thomas H. Walter Waters Corporation, United States Published on September 12, 2025 Abstract Bisphosphonates (BPs) are an important class of…

Application Note Improved Separation of RNA Nucleotides, Nucleosides, and Nucleobases on Atlantis Premier BEH Z-HILIC Columns Kenneth D. Berthelette, Steve Shiner, Thomas H. Walter, Jennifer M. Nguyen, Jonathan E. Turner Waters Corporation Abstract The use of novel HILIC stationary phases…

Application Note Introducing Atlantis BEH Z-HILIC: A Zwitterionic Stationary Phase Based on Hybrid Organic/Inorganic Particles Thomas H. Walter, Kenneth D. Berthelette, Amit Patel, Bonnie A. Alden, Justin McLaughlin, Jessica Field, Nicole Lawrence, Steve Shiner Waters Corporation Abstract Among the many…

Application Note Development and Optimization of a HILICMS Separation of 17 Free Amino Acids using an XBridge Premier BEH Amide Column Kenneth D. Berthelette, Jamie Kalwood, Kim Haynes Waters Corporation Abstract Method development can be an arduous task. While method…