Accelerating Method Development and Manufacturing of GLP-1 Analogs with LCUV/ MS

Application Note Application of LC-UV/MS Workflows to Increase Efficiency in Impurity Profiling of GLP-1 Analogs Duanduan Han, Samantha Ippoliti, Robert E. Birdsall, Karen Nyholm Waters Corporation, United States Published on May 16, 2025 Contact Sales Abstract Glucagon-like-peptide-1 (GLP-1) receptor agonists…

GLP-1 Analog: Accelerating Method Development and Manufacturing with LC-UV/MS M1330-02-09 Erin McAllister, Duanduan Han, Samantha Ippoliti, Robert E. Birdsall, Karen Nyholm Waters Corporation, Milford, MA CONTACT INFORMATION: Erin McAllister [email protected] PURPOSE RESULTS RESULTS Glucagon-like-peptide-1 receptor agonist (GLP-1 RA) Orthogonal screening…

LC-UV/MS Workflows Enabling Orthogonal Impurity Profiling of GLP-1 Analogs Duanduan Han, Robert Birdsall ,Nikhil Bhiwankar Affiliation: Waters Corporation, Milford, MA Introduction Results & Discussion Orthogonal screening for impurity detection • GLP-1 analog: exenatide (exe) Formula: C184H282N50O60S MW = 4,186.6 Da…

Application Note Reversed-Phase LC-MS Analysis of LowAbundance Impurities in a GLP-1a Therapeutic Using a Charged Surface 230Å Superficially Porous Phenyl-Hexyl Column Stephan M. Koza, Stephen J. Shiner, Matthew A. Lauber Waters Corporation, United States Published on July 15, 2026 Abstract…