Structural Characterization of Glycated Monoclonal Antibodies Using Collision Induced Unfolding on the SELECT SERIES™ Cyclic™ IMS Mass Spectrometer

A HIGHLY VERSATILE CYCLIC ION MOBILITY – MASS SPECTROMETER FOR ROUTINE TO IN-DEPTH BIOPHARMACEUTICAL CHARACTERIZATION Brad J. Williams1, Margo Wilson2, S. Hunter Walker2, Greg Adams2, Roy Martin1, and Weibin Chen1 1 Waters Corporation, Milford, MA 01757 USA, 2FUJIFILM Diosynth Biotechnologies,…

Poster Reprint ASMS 2024 Poster number ThP 561 A modified SLIM-IM-QTOF for high resolution collision induced unfolding and native protein analysis Ruwan Kurulugama1, Sarah Stow1, Daniel DeBord2, Greg Kilby2 and Harsha Gunawardena3 1Agilent Technologies, Inc., Santa Clara, CA 2MOBILion Systems,…

Ion Mobility-Mass Spectrometry Reveals the Structures and Stabilities of Biotherapeutic Antibody Aggregates % Daniel D. Vallejo1, Chae K. Jeon1, Kristine F. Parson1, Hayley Herderschee1, Joseph D. Eschweiler2, Ruwan T. Kurulugama3, John C. Fjeldsted3, Dana Filoti2, Brandon T. Ruotolo1 m/z 1Department…

Waters Cyclic IMS P20 Mass Spectrometer Insight—revealed, not inferred. Insight— revealed, not inferred Biological systems are inherently complex, and answering today’s research questions requires tools that can reveal that complexity with clarity. The Waters™ Cyclic™ IMS P20 Mass Spectrometer enables…