Determination of Stoichiometry of Protein-Protein Interactions

W H I T E PA P E R WP3001: SEC-MALS and CG-MALS: Complementary Techniques to Characterize Protein-DNA Complexes Sophia Kenrick, Ph.D., Waters | Wyatt Technology Summary Interactions between proteins and nucleic acids often result in binding stoichiometries greater than…

Light Scattering for the Masses ® Binding Affinity and Stoichiometry of a Multivalent Protein-aptamer Association Summary ecause proteins are often multimeric in their native state, the biomarker targets of many pharmaceuticals present multiple binding sites. In the case of monoclonal…

Volume 28, Number 1 Technical Article by Dan Some and Amy Hanlon Characterizing Protein–Protein Interactions Via Static Light Scattering: Inhibition Kinetics and Dissociation Q uantification of the kinetic rates of protein association, dissociation, and aggregation is an essential factor in…

A P P L I C AT I O N N O T E AN1610: Stoichiometry of intrinsically disordered protein complexes Jan van Dieck, Ph.D., MRC Centre for Protein Engineering, Laboratory of Molecular Biology Introduction The S100 family is a…