Analysis of N-Nitroso-Sertraline in Drug Substance and Tablet Using LC-MS/MS

Application Note Quantitation of N-Nitroso Carvedilol in Drug Substance Using LC-MS/MS Dimple D. Shah, Marian Twohig, Padmakar Wagh, Amy Bartlett, Peter Hancock Waters Corporation Abstract N-nitrosamines are a class of chemical compounds known for their carcinogenic properties, posing significant health…

Application Note Quantitation of N-Nitroso-DesmethylDiltiazem, an NDSRI Impurity of Diltiazem Hydrochloride in Drug Product Using LCMS/MS Pavan Kukkadapua, Marian Twohigb, Padmakar Wagha a Waters Corporation, Bangalore, India b Waters Corporation, Milford, United States Published on August 19, 2026 Abstract Since…

Application Note Quantitation of N-Nitroso-Propranolol in Drug Substance using LC-MS/MS Marian Twohig, Amy Bartlett, Padmakar Wagh Waters Corporation Abstract N-Nitrosamines (nitrosamines) can be potentially mutagenic and carcinogenic. Since 2018, nitrosamines have been discovered in several classes of pharmaceuticals. There have…

Application Note A Sensitive and Cost-Effective LC–MS Method for Quantifying N-Nitroso-Atenolol in Drug Formulation Henry Foddya, Matthew Gregoryb, Joe Lackeyb, Moritz Perscheidb, Neil Walsha a Waters Corporation, Wilmslow, United Kingdom b LGC Standards, Guildford, United Kingdom Published on December 09,…