Charge Variant Characterization of Innovator and Biosimilar Drugs with MauriceFlex™ and BioAccord™ LC-MS System

Novel LCMS-Compatible icIEF Fractionation For Characterization of Innovator and Biosimilar mAbs Srinivasa Rao1, Samantha Ippoliti2, Ying Qing Yu2, Nick Pittman3, Chris Heger1 1Bio-Techne, San Jose, CA; 2Waters Corporation, Milford, MA; 3Waters Corporation, Wilmslow, UK Abstract Results and Discussion Monoclonal antibodies…

MauriceFlex Fractionation of charge variants accompanied by LC-MS and Digital SPR Analysis correlates Structure to the Function of a mAb Srinivasa Rao1, Samantha Ippoliti2, Ying Qing Yu2, Michael Piazza3, Chris Heger1 Bio-Techne1, San Jose, CA; Waters Corporation2, Milford, MA; Nicoya…

Application Note Accelerating Charge Variant Analysis of Biotherapeutics with the BioAccord™ System Robert E. Birdsall, Brooke M. Koshel, Ying Qing Yu Waters Corporation Abstract Ion Exchange Chromatography (IEX) is a valuable technique given its ability to resolve product/process related charge…

Application Note Comprehensive Biosimilar Comparability Assessment via Intact and Subunit RP-MS and IEX-UV-MS Using the Xevo™ G3 QTof System Samantha Ippoliti, Owen Cornwell, Lisa Reid, Ying Qing Yu, Emma Harry, Mark Towers Waters Corporation Abstract With the increasing prevalence of…