Deformulating Size Exclusion Chromatography for LNP Payload Quantitation

mRNA/LNP Multiattribute Quantitation of Payload(s), Size and Heterogeneity With Size Exclusion Chromatography Coupled to Multiangle Light Scattering a b b a Mateusz Imiołek , Lavelay Kizekai , Bala Addepalli , Szabolcs Fekete , Matthew Lauber a - Waters Corporation, Rue…

Application Note Efficient Profiling of Lipid Nanoparticle Formulations Using Waters GTxResolve 2000 Å SEC Column, MaxPeak Premier 3 µm Abraham Samuel Finny, Lavelay Kizekai, Christian Reidy, Mandana Fasth, Balasubrahmanyam Addepalli, Matthew Lauber Waters Corporation, United States Published on May 05,…

AN2615: Multi-attribute quantification of LNP-mRNA therapeutics by FFF-MALS and DLS Martin Kurnik, Ph.D., Wyatt Technology, LLC Summary Introduction Bringing effective and safe lipid nanoparticle-formulated mRNA therapeutics to market requires quantitation of multiple quality attributes throughout development, manufacturing, and quality control.…

Characterizing Nucleic Acid Payloads in Lipid Nanoparticles and Viral Vectors via Charge Detection Mass Spectrometry (CDMS) Rebecca J. D'Esposito1; Alexandre Gomes1, Emily Christofi2; Ying Qing Yu1; Michelle Chen3 1Waters Corporation, Milford, MA; 2Waters Corporation, Wilmslow, United Kingdom; 3Waters Corporation, Goleta,…