Confident transformation site localization of PROTAC drug metabolites facilitated by multi-stage fragmentation LC-MS

Confident transformation site localization of PROTAC drug metabolites facilitated by multi-stage fragmentation LC-HRAM-MS Sven Hackbusch1, Min Du2; 1 Thermo Fisher Scientific, San Jose, CA, USA, 2 Thermo Fisher Scientific, Lexington, MA, USA Abstract Results Flexible MS data acquisition method for…

Pharma and biopharma Accelerating metabolite identification with mass spectrometry Contents 1. Why is metabolite identification critical for drug discovery? Next page 3 1.1. How to perform metabolite identification in drug discovery? 5 1.2. Why is HRAM MS advantageous in metabolite…

White paper | 002154 Pharma Increased confidence in drug metabolite identification through intelligent data acquisition strategies and multiple fragmentation techniques on the Orbitrap Tribrid MS platform Authors Overview Sven Hackbusch¹, Kate Comstock¹, • The LC/MS analysis of drug metabolites relies…

Enhanced Metabolite Identification using Orbitrap™ Tribrid Mass Spectrometer Shuguang Ma, Ph.D. Drug Metabolism and Pharmacokinetics Genentech, Inc. Thermo Fisher Scientific 2018 ASMS Breakfast Workshop, June 04, 2018 Outline  Introduction  Orbitrap ID-X with AcquireX Algorithm and Workflow  Case…