GCxGC-TOFMS Analysis of TMS Derivatives in Urine From a Type I Diabetic Subject for Small Molecule Metabolite Profile

Life Science and Chemical Analysis Centre LECO Corporation, Saint Joseph, Michigan USA Caliper - sample "2_PS_TYPE2:1", 870 , 1.585 sec , sec to 870 , 1.585 sec , sec ALANINE,N,O -TMS 73 1000 116 59 147 190 50 100 150…

® Small Molecule Metabolite Identifications in Diabetic Versus Non-Diabetic Urine Sample Groups Using Comprehensive Two-Dimensional Gas Chromatography Combined with Time-of-Flight Mass Spectrometry (GCxGC-TOFMS) John Heim, LECO Corporation; Saint Joseph, Michigan USA Key Words: Fisher Ratio, Sample Groups, Diabetes, Metabolite Profile…

® Delivering the Right Results GCxGC-TOFMS Data Interpretation of Metabolic Biomarkers from Diabetic and Non-diabetic Urine Utilizing Fisher Ratios Prior to Multivariate Analysis John R. Heim, Scott Pugh, and Mark Libardoni • LECO Corporation, St. Joseph, Michigan OVERVIEW EXPERIMENTAL METHODS…

® Delivering the Right Results Utilization of Comprehensive Two-Dimensional Gas Chromatography Combined with Time of Flight Mass Spectrometry (GCxGC-TOFMS) for Small Metabolite Identifications in Complex Biological Samples John Heim and Mark Libardoni • LECO Corporation, St. Joseph, MI INTRODUCTION EXPERIMENTAL…