Rapid LC-MS Analysis of mAb Charge Variant with a 20 mm Cation Exchange Column

Application Note Accelerating Charge Variant Analysis of Biotherapeutics with the BioAccord™ System Robert E. Birdsall, Brooke M. Koshel, Ying Qing Yu Waters Corporation Abstract Ion Exchange Chromatography (IEX) is a valuable technique given its ability to resolve product/process related charge…

Application Note Rapid mAb Charge Variant Analysis with 20 mm Cation Exchange Columns Hua Yang, Lili Macedo, Stephan M. Koza, Steve Shiner Waters Corporation Abstract Rapid and reliable, 6-minute, cation-exchange (CEX) charge variant analyses of NISTmAb using either a salt…

[ APPLICATION NOTE ] Optimizing LC-MS Separations of mAbs using a BioResolve SCX mAb Column and IonHance CX-MS pH Concentrates Andrew Schmudlach, Samantha Ippoliti, Qi Wang, and Matthew A. Lauber Waters Corporation, Milford, MA, USA APPLICATION BENEFITS INTRODUCTION A novel…

[ APPLICATION NOTE ] Online IEX-MS of mAb Charge Variants Using a BioResolve SCX mAb Column, IonHance CX-MS pH Concentrates, and BioAccord System Samantha Ippoliti, Andrew Schmudlach, Matthew A. Lauber, and Ying Qing Yu Waters Corporation, Milford, MA, USA APPLICATION…