IMPROVED TISSUE HOMOGENIZATION AND SPE-BASED SAMPLE PREPARATIONS FOR THE QUANTITATIVE LC-MS ANALYSIS OF OLIGONUCLEOTIDE THERAPEUTICS

Application Note Improved Bioanalytical Extraction of Therapeutic Antisense Oligonucleotides, Including a Lipid Conjugated ASO From Liver and Brain Tissue Using the OligoWorks™ SPE Microplate Kit Makda Araya, Mary Trudeau, Balasubrahmanyam Addepalli, Matthew A. Lauber Waters Corporation Abstract To develop and…

Application Note Improved Recovery of a Lipid Conjugated Antisense Oligonucleotide from Human Plasma using the OligoWorks™ SPE Microplate Kit and an Optimized Protocol Mary Trudeau, Matthew A. Lauber Waters Corporation This is an Application Brief and does not contain a…

Application Note Quantification of a Lipid Conjugated Antisense Oligonucleotide (ASO) Extracted From Rat Plasma Using the OligoWorks™ SPE Microplate Kit on a HRMS System Nikunj Tanna, Mary Trudeau Waters Corporation Abstract Discovery bioanalysis laboratories play a critical role in the…

BIOANALYTICAL QUANTIFICATION OF A LIPID CONJUGATED ANTI-SENSE OLIGONUCLEOTIDE ON A HRMS SYSTEM Authors: Nikunj Tanna, Joe Fredette and Mary Trudeau Affiliations INTRODUCTION METHODS SPE METHOD OPTIMIZATION Oligonucleotide therapeutics (ONTs) are a key focus area for many drug developers today given…