Fast acquisition of DDA-MS/MS of oligonucleotides and the novel spectral merging algorithm for better assignment of sequence information

Integrated Data Analysis of Oligonucleotide Therapeutics Using LC-MS, LC-MS/MS and MALDI techniques 1 2 2 3 3 3 3 Nishi Rochelle ; Neil J Loftus ; Simon Ashton ; Kosuke Uchiyama ; Risa Suzuki ; Takashi Nishikaze ; Yuka Fujito…

Impurity Profiling and Characterization of Therapeutic Oligonucleotides using Nominal Mass Spectrometry on a Single Quadrupole LC-UV-MS system Risa Suzuki1, 3, Kosuke Uchiyama1, Noriko Kato1, Simon Ashton2, Neil Loftus2, Yuka Fujito1 1Shimadzu Corporation, Kyoto, Japan; 2Shimadzu Corporation, Manchester, United Kingdom; 3Shimadzu…

Single Quadrupole Mass Spectrometry Quick Workflows Specified to Oligonucleotides Screening Kosuke Uchiyama1, Noriko Kato1, Qiuyi Wang1, Simon Ashton2, Neil Loftus2, Risa Suzuki1, 3, Yuka Fujito1 1Shimadzu Corporation, Kyoto, Japan; 2Shimadzu Corporation, Manchester, United Kingdom; 3Shimadzu Scientific Instruments, Inc., Columbia, Maryland…

Application note | 001398 Biopharma Streamlining characterization and monitoring of oligonucleotide impurities using an Orbitrap-based LC-HRAM-MS platform Application benefits Authors Hao Yang , Keeley Murphy , Yi Zhang , 1 2 3 • Comprehensive characterization of oligonucleotides and their impurities…