Monitoring Intact Glycoprofiles and Spent Media Metabolites in Samples from Sartorius Ambr 250 High Throughput Bioreactor System to Support Upstream Process Development

[APPLICATION NOTEBOOK] At-line Solutions for Upstream Bioprocessing Application Notes [APPLICATION NOTEBOOK] Introduction Bioprocessing harnesses the power of living cells to manufacture valuable products such as biological drugs for clinical use. The introduction and use of biologics has revolutionized biotherapeutics to…

COMBINING INTACT GLYCOPROFILING AND CELL CULTURE MEDIA ANALYTICS FOR IN-PROCESS MONITORING OF AN AUTOMATED HIGH-THROUGHPUT MULTI-PARALLEL BIOREACTOR SYSTEM Authors: Yun Alelyunas1; Charles Prochaska2; Clint Kukla2; Guillaume Bechade3; Patrick Boyce3; Mark Wrona1 Affiliations: 1 Waters Corporation, Milford, MA; 2 Sartorius Stedim…

Application Note Simplifying Bioreactor In-Process Monitoring with Waters Bioprocess Walk-Up Solutions Yun Wang Alelyunas, Elizabeth Embrey, Lindsay Collins, Adrien Pegaz-Blanc, Guillaume Mignard, Mark D. Wrona Waters Corporation This is an Application Brief and does not contain a detailed Experimental section.…

Application Note Analytical LC-MS Platform Methodologies to Support Upstream Bioprocess Optimization Yun Alelyunas, Julie Wushensky, Jurgen Sanes, Mark Wrona, Rui Chen Waters Corporation, United States Published on August 18, 2025 Introduction Effective process monitoring and product critical quality attribute analysis…