Salt Plug Injection Methods for Improved Anion Exchange Analyses of Large Nucleic Acids

FAST AND HIGH RECOVERY ANALYTICAL CHARACTERIZATION OF mRNAs USING WEAK ANION EXCHANGE AND ION PAIRING REVERSED PHASE CHROMATOGRAPHY Mateusz IMIOLEK1, Szabolcs FEKETE1, Matthew A. LAUBER2 1Waters Corporation, Geneva, Switzerland, 2Waters Corporation, Milford, MA, USA INTRODUCTION ANION EXCHANGE CHROMATOGRAPHY (AEX) AEX…

Application Note Methods for the Anion Exchange Chromatographic Analysis of mRNAs Szabolcs Fekete, Hua Yang, Stephan M. Koza, Kevin Wyndham, Matthew A. Lauber Waters Corporation Abstract mRNA-based therapeutics and vaccines are a relatively new class of biopharmaceuticals that have demonstrated…

Application Note Implementing Programmed Injection Techniques in Empower™ CDS: A Practical Guide Szabolcs Fekete, Mateusz Imiolek 1 Waters Corporation, Geneva, Switzerland Published on May 26, 2025 Contact Sales Application Brief This is an Application Brief and does not contain a…

Application Note High-Resolution Separations of Single and Double-Stranded Nucleic Acids Using Strong Anion-Exchange Chromatography Abraham S. Finny, Balasubrahmanyam Addepalli, Matthew A. Lauber Waters Corporation, United States Published on November 18, 2025 Abstract High-Resolution Separations of Single and Double-Stranded Nucleic Acids…