Increased Dynamic Range of DDA-based label-free quantification using the CHIMERYS algorithm

The intelligent protein informatics platform Thermo Scientific Proteome Discoverer software Transform proteomics mass spectrometry data into insights Thermo Scientific™ Proteome Discoverer™ software enables comprehensive proteomics data processing workflows empowered by artificial intelligence. • Powerful and flexible framework: Optimized analysis for…

CHIMERYS: An AI-Driven Leap Forward in Peptide Identification Martin Frejno1; Daniel P Zolg1; Tobias Schmidt1; Siegfried Gessulat1; Michael Graber1; Florian Seefried1; Magnus Rathke-Kuhnert1; Samia Ben Fredj1; Shyamnath Premnadh1; Patroklos Samaras1, Kai Fritzemeier2; Frank Berg2; Waqas Nasir2; David Horn3; Bernard Delanghe2;…

CHIMERYS: An AI-Driven Leap Forward in Peptide Identification Martin Frejno1; Daniel P Zolg1; Tobias Schmidt1; Siegfried Gessulat1; Michael Graber1; Florian Seefried1; Magnus Rathke-Kuhnert1; Samia Ben Fredj1; Shyamnath Premnadh1; Kai Fritzemeier2; Frank Berg2; Waqas Nasir2; David Horn3; Bernard Delanghe2; Christoph Henrich2;…

values, or to be used as replicates to generate standard errors. Here we present a new workflow for untargeted label-free quantification using a new feature detection approach that provides the full suite of quantitative capabilities previously only available for isotopicallylabeled…