Comparison of therapeutic antibody originator and biosimilar glycosylation using an integrated glycan labeling solution

[ APPLICATION NOTE ] Increasing Productivity and Confidence for N-linked Glycan Analysis of Biosimilars Using the BioAccord System Ximo Zhang, Corey Reed, Henry Shion, William Alley, Robert Birdsall, and Ying Qing Yu Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■■…

IMPROVING CONFIDENCE AND PRODUCTIVITY FOR N-LINKED GLYCAN ANALYSIS IN BIOTHERAPEUTICS DEVELOPMENT USING AN INTEGRATED UPLC-FLR-HRMS SYSTEM Ximo Zhang; Corey Reed, Henry Shion, Robert Birdsall; Ying Qing Yu Scientific Operations, Waters Corporation, Milford, MA INTRODUCTION RESULTS AND DISCUSSION Due to the…

APPLICATION NOTE 22060 Understanding the effects of column temperature on high resolution glycan separations Authors: Zoltan Szabo, Thermo Fisher Scientific, Sunnyvale, CA, USA Kean Woodmansey, Thermo Fisher Scientific, Runcorn, United Kingdom Stacy Tremintin, Thermo Fisher Scientific, Sunnyvale, CA, USA Keywords:…

Robustness of Rapi Fluor-MS N-Glycan Sample Preparations and Glycan BEH Amide HILIC Chromatographic Separations Matthew A. Lauber,1 Michael F. Morris,1 Darryl W. Brousmiche,1 and Stephan M. Koza1 Waters Corporation, Milford, MA, USA 1 A P P L I C AT…