Increasing Productivity and Confidence for N-linked Glycan Analysis of Biosimilars Using the BioAccord System

IMPROVING CONFIDENCE AND PRODUCTIVITY FOR N-LINKED GLYCAN ANALYSIS IN BIOTHERAPEUTICS DEVELOPMENT USING AN INTEGRATED UPLC-FLR-HRMS SYSTEM Ximo Zhang; Corey Reed, Henry Shion, Robert Birdsall; Ying Qing Yu Scientific Operations, Waters Corporation, Milford, MA INTRODUCTION RESULTS AND DISCUSSION Due to the…

Application Note Characterization of Released N-linked Glycans in Biosimilar mAb Drug Products Using the Xevo™ G3 QTof Kellen DeLaney, Yamin Htet, Ying Qing Yu Waters Corporation Abstract As an increasing number of biosimilar monoclonal antibodies (mAb) are being developed, there…

[ APPLICATION NOTE ] Combining RapiFluor-MS and UNIFI Scientific Information System for a Total N-linked Glycan Solution for Innovator vs. Biosimilar Infliximab Comparisons William R. Alley, Jr. and Ying Qing Yu Waters Corporation, Milford, MA, USA APPLICATION BENEFITS INTRODUCTION This…

BIOPHARMACEUTICAL PLATFORM SOLUTION Key Applications TABLE OF CONTENTS Biopharmaceutical Platform Solution with UNIFI: Key Applications Intact Protein MS Analysis I Peptide Mapping I Released Glycan Analysis I Bioseparations Biotherapeutic proteins – such as monoclonal antibodies (mAbs), biosimilars, and antibody drug…