Quantification of Underivatized Amino Acids in Cell Culture Media Using the BioAccord LC-MS System

[APPLICATION NOTEBOOK] At-line Solutions for Upstream Bioprocessing Application Notes [APPLICATION NOTEBOOK] Introduction Bioprocessing harnesses the power of living cells to manufacture valuable products such as biological drugs for clinical use. The introduction and use of biologics has revolutionized biotherapeutics to…

Application Note Introducing a Rapid Throughput LC-MS Method for Cell Culture Media Nutrient and Metabolite Analysis Supporting Upstream Bioprocessing Yun Wang Alelyunas, Josh Gray, Mark D. Wrona, Patrick Boyce Waters Corporation Abstract A nine-minute rapid and direct liquid chromatography and…

A High Throughput LC-MS Method for Cell Culture Media Nutrient and Metabolite Analysis Supporting Upstream Bioprocessing Yun W. Alelyunas, Josh Gray, Guillaume Bechade, Courtney Walton, Mark D. Wrona, Waters Technology Corporation, Milford, MA INTRODUCTION METHODS RESULTS A 9-minute rapid and…

Upstream LC-MS Monitoring of Cell Culture and Microbial Growth Media Supporting Bioprocess Development Yun W. Alelyunas, Mark D Wrona, Ying Qing Yu, Dominic Levasseur, Ann Gray, Suraj Dhungana, Waters Technologies Corporation, 34 Maple St, Milford MA System / informatics overview…