A High Throughput LC-MS Method for Cell Culture Media Nutrient and Metabolite Analysis Supporting Upstream Bioprocessing

Application Note Introducing a Rapid Throughput LC-MS Method for Cell Culture Media Nutrient and Metabolite Analysis Supporting Upstream Bioprocessing Yun Wang Alelyunas, Josh Gray, Mark D. Wrona, Patrick Boyce Waters Corporation Abstract A nine-minute rapid and direct liquid chromatography and…

[APPLICATION NOTEBOOK] At-line Solutions for Upstream Bioprocessing Application Notes [APPLICATION NOTEBOOK] Introduction Bioprocessing harnesses the power of living cells to manufacture valuable products such as biological drugs for clinical use. The introduction and use of biologics has revolutionized biotherapeutics to…

Application Note Analytical LC-MS Platform Methodologies to Support Upstream Bioprocess Optimization Yun Alelyunas, Julie Wushensky, Jurgen Sanes, Mark Wrona, Rui Chen Waters Corporation, United States Published on August 18, 2025 Introduction Effective process monitoring and product critical quality attribute analysis…

Application Note Integrating LC–MS Spent Media Analytics with DoE for Rational Feed Optimization in mAb Manufacturing Richard Jeske, Fang Lu, Yun Alelyunas, Julie Wushensky, Chandler Przybylski, Rui Chen Waters Corporation, Immerse™ Lab Delaware, United States Published on March 18, 2026…