Evaluation of Bench-top Quadrupole Orbitrap Ultra High Resolution MS for Use in Clinical Research in Rapid Quantitative Analysis of Vitamin D in Human Plasma

Ap plica t ion Note 63 6 Rapid Analysis of 25-Hydroxyvitamin D3, epi-25-Hydroxyvitamin D3, and 25-Hydroxyvitamin D2 in Plasma for Clinical Research Using High-Resolution Mass Spectrometry Mindy Gao, James Goldberg, Thomas Carrell, and Marta Kozak Thermo Fisher Scientific, San Jose,…

Mindy Gao, Joe Di Bussolo, Marta Kozak Thermo Fisher Scientific, San Jose, CA Key Words Q Exactive Focus, methylmalonic acid, MMA, clinical research Goal To evaluate the performance of the Thermo Scientific™ Q Exactive™ Focus benchtop quadrupole-Orbitrap mass spectrometer as…

Methods Calibrators Calibrators containing cyclosporin A, everolimus, sirolimus, and tacrolimus in whole blood were purchased from Chromsystems Instruments & Chemicals GmbH (TABLE 1). Evaluation of Benchtop Quadrupole Orbitrap Ultra-High-Resolution Mass Spectrometer in Rapid Quantitative Analysis of Immunosuppressant Evaluation of Benchtop…

High-Resolution Accurate-Mass (HRAM) Phthalate Screening using Direct Analysis in Real Time (DART) Ambient Ionization Catharina Crone,1 Markus Kellmann,1 Yue Xuan,1 Elizabeth Crawford2 1 Thermo Fisher Scientific, Bremen, Germany; 2IonSense, Inc., Saugus, MA, USA Overview Purpose: Demonstrating the analysis of phthalic…