CASSS: Developing a high-resolution LC-MS method for spent media analysis in biopharm upstream process development

[APPLICATION NOTEBOOK] At-line Solutions for Upstream Bioprocessing Application Notes [APPLICATION NOTEBOOK] Introduction Bioprocessing harnesses the power of living cells to manufacture valuable products such as biological drugs for clinical use. The introduction and use of biologics has revolutionized biotherapeutics to…

Application Note Introducing a Rapid Throughput LC-MS Method for Cell Culture Media Nutrient and Metabolite Analysis Supporting Upstream Bioprocessing Yun Wang Alelyunas, Josh Gray, Mark D. Wrona, Patrick Boyce Waters Corporation Abstract A nine-minute rapid and direct liquid chromatography and…

Application Note Monitoring Nutrients and Metabolites in Spent Cell Culture Media for Bioprocess Development Using the BioAccord LC-MS System With ACQUITY Premier Yun Wang Alelyunas, Mark D. Wrona Waters Corporation Abstract In biotherapeutics process development, cell culture media solution provides…

A High Throughput LC-MS Method for Cell Culture Media Nutrient and Metabolite Analysis Supporting Upstream Bioprocessing Yun W. Alelyunas, Josh Gray, Guillaume Bechade, Courtney Walton, Mark D. Wrona, Waters Technology Corporation, Milford, MA INTRODUCTION METHODS RESULTS A 9-minute rapid and…