The Micronization of Drug Particles by the Rapid Expansion of a Supercritical Solution

SCF 527 Precipitation of Protein Powders into a Compressed Antisolvent lyophilization, and using miscible organic antisolvents. Unfortunately, these processes can also inactivate or denature proteins, produce small final yields, lead to electrostatically charged powders, produce particles with a broad distribution,…

SCF 528 Precipitation of Protein Powders by Gas Anti-Solvent (GAS) Introduction The pharmaceutical and health care industries are seeking new methods of administering protein powders. Whether delivered in encapsulated formations, aerosol delivery, or implanted controlled release systems, it is essential…

SCF 535 Determination of Steroids in Animal Tissues by Supercritical Fluid Extraction and Inline Trapping Introduction The use of anabolic steroids in food producing animals is illegal among countries in the European Union. In order to enforce regulations, laboratories responsible…

SCF 520 Extraction of Drugs and other Chemical Residues from Tissues using SPE Trapping Techniques Isolation of Drug Residue from Tissue Matrices by SFE There have been some problems identified with using typical SFE methods to isolate drug residue from…