Adeno-Associated Virus Identity Confirmation in Biopharma by LC/MS

Application Note LC/MS of Intact Adeno-Associated Virus Capsid Proteins for Rapid Confirmation of Product Identity Author Brian Liau Agilent Technologies, Inc. Introduction Adeno-associated viruses (AAVs) are a promising new class of biotherapeutic capable of treating a host of rare and…

Application Note Pharma & Biopharma Characterization of Viral Vector Particles Using the Agilent 6545XT AdvanceBio LC/Q-TOF Authors Wendi A. Hale and Christopher M. Colangelo Agilent Technologies, Inc., Lexington, MA, USA Roy Hegedus and Norman Garceau Lake Pharma, Worcester, MA, USA…

Consumables Workflow Ordering Guide Host Cell Protein Analysis by RP-LC/MS Unlike small molecules and oligos, mAbs and other protein-based therapeutics, including adeno-associated virus (AAV) capsids are engineered and produced using a cell line. These cell lines include CHO (Chinese Hamster…

Poster Reprint ASMS 2020 ThP 466 Purity and Identity Characterization of AdenoAssociated Virus Capsid Particles by Intact and BottomUp Based Liquid Chromatography-Mass Spectrometry Methods Wendi A. Hale1, Dominique Garceau2, Tristan Cano2, Caitlin Jaeger2, Roy Hegedus2, William Hermans2, Norman Garceau2, Christopher…